期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 197-206出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S121249
关键词
iron oxide nanoparticles; surface functionalization; bioactive glycosaminoglycan; magnetic resonance imaging; cellular uptake; breast carcinoma
资金
- National Natural Science Foundation of China [81201087, 81571665, 21074152, 51273216, J1103305]
- 973 Program of China [2015CB755500]
- Guangzhou Key Technology RD Program [1563000477, 201607010038]
- Natural Science Foundation of Guangdong Province in China [10151006001000010, 2014A030313647]
Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HASPIONs. When incubated with CD44 HA receptor-overexpressing MDA-MB-231 cells in vitro, HA-SPIONs exhibited significant specific cellular uptake and specific accumulation confirmed by Prussian blue staining. The in vitro and in vivo results of magnetic resonance imaging and photothermal ablation demonstrated that HA-SPIONs exhibited significant negative contrast enhancement on T-2-weighted magnetic resonance imaging and photothermal effect targeted CD44 HA receptor-overexpressing breast cancer. All these results indicated that HA-SPIONs have great potential for effective diagnosis and treatment of cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据