期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 11, 期 -, 页码 3475-3485出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S106073
关键词
gold clusters; in vivo toxicity; long-term; cancer therapy
资金
- National Natural Science Foundation of China [81471786, 11304220, 81000668]
- Natural Science Foundation of Tianjin [13JCQNJC13500, 14JCYBJC26700]
- Subject Development Foundation of Institute of Radiation Medicine, CAMS [SF1601, SF1503]
Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clinical contrast reagents, but these properties are yet to be fully investigated. In this study, we prepared glutathione-protected Au NCs of a similar hydrodynamic size but with three different surface charges: positive, negative, and neutral. Their in vivo biodistribution, excretion, and toxicity were investigated over a 90-day period, and tumor uptake and potential application to radiation therapy were also evaluated. The results showed that the surface charge greatly influenced pharmacokinetics, particularly renal excretion and accumulation in kidney, liver, spleen, and testis. Negatively charged Au NCs displayed lower excretion and increased tumor uptake, indicating a potential for NC-based therapeutics, whereas positively charged clusters caused transient side effects on the peripheral blood system.
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