期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 -出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S117498
关键词
TiO2 nanotubes; electrochemical anodization; modification; stimulated drug delivery; drug-releasing implant
资金
- National Natural Science Foundation of China [21501127, 51502185]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of People's Republic of China [15KJB430025]
- Wenzhou government's start-up fund [WIBEZD2014005-01, WIBEZD2014005-04]
- project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Project for Jiangsu Scientific and Technological Innovation Team
To address the limitations of traditional drug delivery, TiO2 nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future.
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