Antiviral effect of mouthwashes against SARS-COV-2: A systematic review

Article Otorhinolaryngology

Efficacy of Povidone-Iodine Nasal and Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)

Jesse S. Pelletier et al.

Summary: The study demonstrated that povidone iodine nasal and oral antiseptic formulations were effective at completely inactivating SARS-CoV-2 virus within 60 seconds, potentially reducing the transmission of COVID-19.

ENT-EAR NOSE & THROAT JOURNAL (2021)

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Article Multidisciplinary Sciences

Salivary SARS-CoV-2 load reduction with mouthwash use: A randomized pilot clinical trial

Fernanda de Paula Eduardo et al.

Summary: The study showed that mouthwash containing cetylpyridinium chloride plus zinc lactate and chlorhexidine gluconate significantly reduced the SARS-CoV-2 viral load in saliva up to 60 minutes after rinsing, while hydrogen peroxide mouthwash resulted in a significant reduction up to 30 minutes after rinsing.

HELIYON (2021)

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Review Dentistry, Oral Surgery & Medicine

Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2

F. Carrouel et al.

Summary: The oral cavity is believed to play an important role in the pathogenicity and transmission of SARS-CoV-2, and the identification of targeted antiviral mouth rinses is crucial for reducing the COVID-19 pandemic. While no significant clinical studies have been conducted yet, examining commercial mouth rinses for reagents with specific antiviral properties against SARS-CoV-2 is important. Targeting the outer lipid membrane of the enveloped virus and denaturing proteins in the capsid are potential strategies for controlling the viral load in the oral cavity.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Dentistry, Oral Surgery & Medicine

Virucidal Activity of the Antiseptic Mouthwash and Dental Gel Containing Anionic Phthalocyanine Derivative: In vitro Study

Caique Santos et al.

Summary: This study demonstrated the in vitro virucidal action of a dental gel and mouthwash containing an anionic phthalocyanine derivative, with the dental gel showing a higher percentage of viral inactivation compared to the mouthwash. The research followed standard protocols and practices recommended by health agencies and showed promising results in reducing the viability of SARS-CoV-2 virus particles.

CLINICAL COSMETIC AND INVESTIGATIONAL DENTISTRY (2021)

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Review Microbiology

Review of the use of nasal and oral antiseptics during a global pandemic

Christopher Stathis et al.

Summary: The review suggests that commonly used antiseptics should be studied in clinical trials to mitigate the progression and transmission of SARS-CoV-2. Current research shows these antiseptics can significantly reduce viral load in vitro and may be used for prevention and early treatment.

FUTURE MICROBIOLOGY (2021)

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Article Infectious Diseases

Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial

Florence Carrouel et al.

Summary: The commercially available mouthwash with beta-cyclodextrin and citrox can effectively reduce the salivary viral load of SARS-CoV-2, showing significant short-term and long-term benefits over the placebo group on day 1 and day 7 respectively.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Infectious Diseases

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore

Chaminda J. Seneviratne et al.

Summary: The study found that using cetylpyridinium chloride and povidone-iodine mouth rinses can effectively reduce the salivary SARS-CoV-2 viral load in COVID-19 patients. Especially in high-risk procedures such as dental treatment, using these mouth rinses may help reduce the risk of virus transmission.

INFECTION (2021)

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Letter Otorhinolaryngology

Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial

Jeremy Guenezan et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2021)

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Article Microbiology

Inactivation of SARS-CoV-2 through Treatment with the Mouth Rinsing Solutions ViruProX(R) and BacterX(R) Pro

Julia Koch-Heier et al.

Summary: Preprocedural mouth rinses with ViruProX(R) or BacterX(R) pro containing CPC and H2O2 or CHX, CPC, and F- successfully inactivated infectious SARS-CoV-2 particles within 30 seconds. While a combination of CPC and CHX as well as CPC alone led to a significant reduction of infectious viral particles, H2O2 and CHX alone had no virucidal effect against SARS-CoV-2.

MICROORGANISMS (2021)

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Article Microbiology

Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro

Chuan Xu et al.

Summary: The study found that mouth rinses like Colgate Peroxyl and povidone-iodine can significantly reduce the infectivity of SARS-CoV-2 virus. The antiviral activities of these rinses were linked to cellular damage, with prolonged effects enhancing their efficacy.

PATHOGENS (2021)

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Article Dentistry, Oral Surgery & Medicine

Dental biofilm of symptomatic COVID-19 patients harbours SARS-CoV-2

Sabrina Carvalho Gomes et al.

Summary: This study found that dental biofilms from symptomatic COVID-19 patients contain SARS-CoV-2 RNA, potentially serving as an important reservoir for COVID-19 transmission.

JOURNAL OF CLINICAL PERIODONTOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Effective in vitro inactivation of SARS-CoV-2 by commercially available mouthwashes

Katherine Davies et al.

Summary: This study evaluated the efficacy of seven commercially available mouthwashes in inactivating SARS-CoV-2, showing significant reductions in viral titres with specific mouthwash formulations. Mouthwashes containing stabilised hypochlorous acid, povidone iodine, and alcohol-based or alcohol-free formulations were effective, while those containing hydrogen peroxide or chlorhexidine gluconate were not effective. These findings have important implications for infection control in dental settings and beyond.

JOURNAL OF GENERAL VIROLOGY (2021)

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Article Virology

Performance of Self-Collected Saliva Testing Compared with Nasopharyngeal Swab Testing for the Detection of SARS-CoV-2

Florence Carrouel et al.

Summary: The study showed that self-collected pure saliva samples are comparable to nasopharyngeal swabs in detecting SARS-CoV-2 viral load in asymptomatic, mild COVID-19 patients, with a significant correlation in viral load between the two sample collection methods.

VIRUSES-BASEL (2021)

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Article Otorhinolaryngology

Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study

Matthias Schurmann et al.

Summary: The study aimed to confirm the effectiveness of over the counter mouthwash solutions in reducing viral load in the saliva of COVID-19 patients and investigating the potential immune modulation effects. The results showed that the mouth rinsing solution reduced viral load by about 90% in most patients and the effects lasted for approximately 6 hours. Further research is needed to explore the potential benefits of using zinc and dexpanthenol in mouthwash formulations for improving patients' health.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro

J. Munoz-Basagoiti et al.

Summary: Cetylpyridinium chloride (CPC) in oral mouthwashes reduces SARS-CoV-2 infectivity by disrupting the integrity of the viral envelope and inhibiting the fusion with target cells. This antiviral activity is effective against different SARS-CoV-2 variants, making CPC-containing mouth rinses a cost-effective measure to reduce viral transmission from infected individuals.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Immunology