期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 11, 期 -, 页码 3397-3416出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S108812
关键词
microchannel emulsification; high-throughput synthesis; drug-loaded polymer nanoparticles; passive mixing; numerical modeling
资金
- EU CIG-Marie Curie under the REA grant [321642]
- ERC Consolidator Grant [ERC-2013-CoG-614715]
By using interdigital microfluidic reactors, monodisperse poly(D,L lactic-co-glycolic acid) nanoparticles (NPs) can be produced in a continuous manner and at a large scale (similar to 10 g/h). An optimized synthesis protocol was obtained by selecting the appropriated passive mixer and fluid flow conditions to produce monodisperse NPs. A reduced NP polydispersity was obtained when using the microfluidic platform compared with the one obtained with NPs produced in a conventional discontinuous batch reactor. Cyclosporin, an immunosuppressant drug, was used as a model to validate the efficiency of the microfluidic platform to produce drug-loaded monodisperse poly(D, L lactic-co-glycolic acid) NPs. The influence of the mixer geometries and temperatures were analyzed, and the experimental results were corroborated by using computational fluid dynamic three-dimensional simulations. Flow patterns, mixing times, and mixing efficiencies were calculated, and the model supported with experimental results. The progress of mixing in the interdigital mixer was quantified by using the volume fractions of the organic and aqueous phases used during the emulsification-evaporation process. The developed model and methods were applied to determine the required time for achieving a complete mixing in each microreactor at different fluid flow conditions, temperatures, and mixing rates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据