期刊
RESPIRATORY INVESTIGATION
卷 60, 期 3, 页码 393-399出版社
ELSEVIER
DOI: 10.1016/j.resinv.2021.11.014
关键词
Carcinoembryonic antigen; Cytokeratin 19 fragment; Non-small cell lung cancer; S-1; Predictive marker
This study retrospectively screened 108 patients with advanced NSCLC treated with S-1 monotherapy and found that patients with high serum CYFRA 21-1 levels had shorter progression-free survival and overall survival, indicating CYFRA 21-1 as a predictive and prognostic marker.
Background: S-1, an oral fluoropyrimidine derivative, is widely used for the treatment of several solid tumors. However, there are no predictive markers for its effectiveness.Methods: We retrospectively screened 108 patients with advanced non-small cell lung cancer (NSCLC) treated via S-1 monotherapy and investigated its relationship with cyto-keratin 19 fragment (CYFRA 21-1) and CEA pretreatment levels.Results: Sixty-one patients with high CYFRA 21-1 levels had a statistically significant shorter progression-free survival (PFS) and overall survival (OS) than 46 patients with normal levels (median PFS = 42 days vs. 70 days, respectively; p = 0.0014; median OS = 197 days vs. 316 days, respectively, p = 0.0239).Conclusions: Serum CYFRA 21-1 levels have predictive and prognostic roles in the man-agement of patients with advanced NSCLC on S-1 monotherapy.(c) 2022 Published by Elsevier B.V. on behalf of The Japanese Respiratory Society.
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