期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 9, 页码 -出版社
MDPI AG
DOI: 10.3390/ijms17091395
关键词
oridonin; ent-kaurane; medicinal chemistry; structural modification; biological activity
资金
- National Natural Science Foundation of China [81373280, 21502121]
- China Post-Doctoral Science Foundation [2015M570258]
- Department of Education in Liaoning Province [L2014382]
- Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)
- Ministry of the Education of China [CMEMR2015-B07]
- Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy [KF-XY-201401]
- Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University
Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon species. It exhibits inhibitory activities against a variety of tumor cells, and pharmacological study shows that oridonin could inhibit cell proliferation, DNA, RNA and protein synthesis of cancer cells, induce apoptosis and exhibit an antimutagenic effect. In addition, the large amount of the commercially-available supply is also very important for the natural lead oridonin. Moreover, the good stability, suitable molecular weight and drug-like property guarantee its further generation of a natural-like compound library. Oridonin has become the hot molecule in recent years, and from the year 2010, more than 200 publications can be found. In this review, we summarize the synthetic medicinal chemistry work of oridonin from the first publication 40 years ago and share our research experience of oridonin for about 10 years, which may provide useful information to those who are interested in this research field.
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