期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms17030300
关键词
insulin resistance; gut microbiota; choline; obesity; bile acids; NAFLD
资金
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning from Shanghai Municipal Education Commission
- Shanghai Pujiang Program from the Science and Technology Commission of Shanghai Municipality [14PJD031]
- Shanghai Creative Research Fund of Higher Education [ZYX-CXYJ-017]
Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据