4.0 Article

Ingestion of orange juice prevents hyperglycemia and increases plasma miR-375 expression

期刊

CLINICAL NUTRITION ESPEN
卷 47, 期 -, 页码 240-245

出版社

ELSEVIER
DOI: 10.1016/j.clnesp.2021.12.003

关键词

Western diet; Orange juice; Glycemia circulating miRNA; Pancreatic beta-cell

资金

  1. Sao Paulo Research Foundation (FAPESP) [2014/22864-0, 2013/07914-8]

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This study found that the intake of high-fat, high-carbohydrate (HFHC) meals with orange juice can modulate the expression of miRNAs linked to pancreatic beta-cell function. In a crossover design study involving twelve healthy subjects, it was observed that the intake of HFHC meal + orange juice increased the expression of plasma miR-375, which is a biomarker of pancreatic beta-cell function, and contributed to preventing hyperglycemia.
Background & aims: The intake of high-fat, high-carbohydrate (HFHC) meals is associated with an increased risk of type 2 diabetes. There is evidence that the association of orange juice to a HFHC meal can modulate the expression of microRNAs (miRNAs) linked to pancreatic beta-cell function such as miR-375. We evaluated the effect of a commercial orange juice intake with HFHC meal on plasma miRNAs expression in twelve healthy subjects in a crossover design study. Methods: Subjects ingested water, orange juice, or an isocaloric beverage along with a 1037 kcal HFHC meal. Blood glucose and miRNAs were evaluated at baseline and 1, 3, and 5 h after the intake. Results: The area under the curve (AUC) for glycemia after ingestion of HFHC + orange juice did not differ from ingestion of HPHC + glucose or HFHC + water. However, the AUC was higher in HFHC meal + glucose compared to HFHC meal + water (p = 0.034). Glucose and insulin concentrations were significantly higher in HFHC meal + glucose group after 1 h, when compared with other groups and times (p < 0.001). There was an increase in plasma miR-375 expression after 3 h of ingestion of HFHC + orange juice versus water (p = 0.026), and a decrease in plasma miR-205-5p expression after HFHC meal + glucose versus water (p = 0.023). Conclusions: A single HFHC meal + orange juice modulated plasma miR-375 expression, which is a biomarker of pancreatic beta-cell function, and contributed to preventing hyperglycemia. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

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