Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study

The present study was done to assess the diagnostic utility of serum netrin-1 and netrin-4 for recog-nising the acute coronary syndrome (ACS) in type 2 diabetes mellitus (T2DM) patients. Forty-two T2DM patients with ACS (Cases) and forty-two T2DM patients without ACS (Controls) were compared. Cases had lower serum netrin-1 and netrin-4 levels than controls and were negatively associated with creatinine kinase-total, creatinine kinase-MB, troponin-T and H-FABP. ROC analysis showed that netrin-1 and netrin-4 had good sensitivity and specificity for ACS prediction in T2DM patients. Serum netrin-1 and netrin-4 levels might be considered complementary markers for ACS diagnosis in T2DM patients. (C) 2021 Cardiological Society of India. Published by Elsevier B.V.

Automated summary

The present study aimed to assess the diagnostic value of serum netrin-1 and netrin-4 in recognizing acute coronary syndrome (ACS) in patients with type 2 diabetes mellitus (T2DM). It was found that T2DM patients with ACS had lower levels of serum netrin-1 and netrin-4, which were negatively associated with other biochemical markers. ROC analysis showed that netrin-1 and netrin-4 had good sensitivity and specificity for predicting ACS in T2DM patients. Therefore, serum netrin-1 and netrin-4 levels could be considered as complementary markers for ACS diagnosis in T2DM patients.