期刊
EVOLUTIONARY ANTHROPOLOGY
卷 31, 期 2, 页码 75-91出版社
WILEY
DOI: 10.1002/evan.21930
关键词
circumpolar; cold stress; development; human energetics; metabolism; phenotypic plasticity
类别
Human adaptability and variations in BAT are shaped by multiple adaptive modes, with plasticity playing a crucial role in successfully adapting to cold climates and undergoing genetic adaptive selection.
While human adaptability is regarded as a classical topic in anthropology, recent work provides new insight into metabolic adaptations to cold climates and the role of phenotypic plasticity in human evolution. A growing body of literature demonstrates that adults retain brown adipose tissue (BAT) which may play a role in non-shivering thermogenesis. In this narrative review, we apply the timescales of adaptation framework in order to explore the adaptive significance of human BAT. Human variation in BAT is shaped by multiple adaptive modes (i.e., allostasis, acclimatization, developmental adaptation, epigenetic inheritance, and genetic adaptation), and together the adaptive modes act as an integrated system. We hypothesize that plasticity in BAT facilitated the successful expansion of human populations into circumpolar regions, allowing for selection of genetic adaptations to cold climates to take place. Future research rooted in human energetics and biocultural perspectives is essential for understanding BAT's adaptive and health significance.
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