期刊
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
卷 20, 期 2, 页码 87-90出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/14779072.2022.2044305
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Recent reports have highlighted rare cases of myocarditis and pericarditis in male adolescents and young adults following COVID-19 mRNA vaccination. The development of acute myocarditis and pericarditis in these individuals may be attributed to age-related lower levels of T-bet and PD-1, predisposing them to autoreactive CD8+CTL release due to T-bet polymorphism. The higher incidence of myocarditis or pericarditis in men compared to women could potentially be explained by estrogen-induced upregulation of T-Bet and PD-1.
Rare cases of myocarditis and pericarditis after COVID-19 mRNA vaccination have been recently reported in male adolescents and young adults. Acute myocarditis and pericarditis following COVID-19 mRNA vaccination in male adolescents and young adults may be connected with age-related lower levels of T-bet and PD-1 in predisposed individulas with T-bet polymorphisms by the release od autoreactive CD8+CTL. Upregulatiomn of T-Bet and PD-1 by estrogen might explai the higher incidence of men developing myocarditis or pericarditis in comparison to women.
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