期刊
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
卷 395, 期 -, 页码 27-35出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2015.11.010
关键词
LA-ICP-MS; Imaging; Metal; Visual Basic for Applications; Visualization; Excel
资金
- German Research Foundation [DFG/TRR57 P13, Q3]
- Interdisciplinary Centre for Clinical Research within the Faculty of Medicine at the RWTH Aachen University [IZKF E7-6]
- Austrian Science Fund (FWF) [Q3] Funding Source: Austrian Science Fund (FWF)
The spatial distribution of metals in biological tissue is an important field in biomedical research. Based on the fundamental significance of metals in health, many metal imaging analysis methods were developed during the last decades. Metal and non-metal imaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is an effective mean to obtain data in high spatial resolution and sensitivity. Unfortunately, the visualization of metal measurements normally needs special software solutions. This work reports the development of a new software tool allowing the reconstruction of metal distribution maps using Microsoft Excel 2007 with the aid of Visual Basic for Applications (VBA) user-defined functions. This routine uses continuous lists of measured data points as raw input. A key step is the determination of the correct length of measurement lines to constitute images without shearing. Adaption to special requirements is easy. It permits the fast generation of high quality scaled images from Microsoft Excel. Moreover, the visualization tool is simply transferable to other systems and can export the images in common image formats such as TIFF or JPG which then can be read out by established image treatment and region of interest handling software such as Image J. (C) 2015 Elsevier B.V. All rights reserved.
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