期刊
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
卷 405, 期 -, 页码 32-38出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2016.05.016
关键词
Direct injection analysis; FT-ICR MS; Comparative study; Chemical constituents; Kudiezi injection
In order to evaluate the performance of direct injection analysis (DIA) and liquid chromatography-mass spectrometry (LC-MS) with ESI-FT-ICR MS on identification of chemical constituents in traditional Chinese medicines (TCMs), Kudiezi injection was selected and analyzed as a sample by both methods. The discovery and identification capacities of two methods were compared, and MS/MS experiments were also carried out to identify chemical constituents. Except 5 components were not detected by DIA FT-ICR MS, other 42 chemical constituents were all tentatively identified by both methods, including phenolic acids, nucleosides, flavonoids and sesquiterpene lactones. It indicated that FT-ICR MS was suitable for identification of chemical constituents in TCMs. And DIA FT-ICR MS had comparable identification capability to LC FT-ICR MS but consumed only 2 min of the analysis time. Therefore, DIA FT-ICR MS could be recommended to be a fast identification strategy for TCMs, while LC FT-ICR MS could be necessary when comprehensive screening and identification of chemical constituents in TCMs. (C) 2016 Published by Elsevier B.V.
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