4.5 Review

The role of exercise on peripheral nerve regeneration: from animal model to clinical application

期刊

HELIYON
卷 7, 期 11, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2021.e08281

关键词

Nerve injury; Nerve regeneration; Physical exercise; Therapeutic exercise

资金

  1. University Research Project Grant (PIACERI Found - NATURE-OA - 2020-2022), Department of Biomed-ical and Biotechnological Sciences (BIOMETEC), University of Catania, Italy

向作者/读者索取更多资源

Peripheral nerve injury can lead to sensory and motor deficits, lifelong disability, and significant socioeconomic costs globally. Exercise promotes physical and psychological well-being and has potential benefits for peripheral nerve regeneration.
Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important socioeconomic costs worldwide. Despite the increase in knowledge of the mechanisms of injury and regeneration, a full functional recovery is still unsatisfying in the majority of patients. It is well known that exercise promotes physical and psychological well-being, by ameliorating general health. In the last years, there has been a growing interest in evaluating the effects of exercise on the peripheral nervous system. Experimental works with rodent models showed the potential utility of exercise following peripheral nerve injuries, as evinced by increasing axon regeneration, muscle reinnervation, better recovery of strength, muscle mass and higher expression of neurotrophic factors. Moreover, clinical evidence showed positive trends in favour of physical therapy following peripheral nerve damage based on the improvement of range of motion (ROM), muscle power grade and pain. After a brief overview of peripheral nerve anatomy and the different types of nerve injury, the present review aims to summarize the impact of exercise on peripheral nerve regeneration. Some clinical evidence regarding the effect of exercise after peripheral nerve injury will also be discussed.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据