期刊
HELIYON
卷 8, 期 1, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2022.e08756
关键词
Peripheral artery disease; IGF-I receptor; Insulin receptor; Androgen receptor; PAD; AR; IGF-IR; IR
资金
- Department of Excellence 2018-2022
- [3407/2018]-PON RI 2014-2020]
This study examined the expression of AR, IGF-IR, and IR in the arterial vessel walls of PAD patients and found that the expression levels of these receptors gradually decreased as the severity of the disease increased.
Background: Peripheral artery disease (PAD) of the lower limbs is a common condition that can affect quality of life. Androgen receptor (AR) can exert sex-specific effects on metabolic system, endothelial function and vascular tone. IGF-I receptor (IGF-IR) and insulin receptor (IR) may also be involved in the aforementioned functions. The aim of this study was to evaluate AR, IGF-IR and IR expression in the arterial vessel walls of PAD patients. Results: This is a cross-sectional study examining 30 males with PAD undergoing open surgery procedures. Mean age was 75.9 +/- 8.8y. All patients belonged to Rutherford stage 4-6. Median expression levels of IR, IGF-IR and AR significantly decreased from stage 4-6 (p < 0.05). Significance: The study evidenced a progressive decrease of IR, IGF-IR and AR expression as the severity of disease increased. Altered levels of IR, IGF-IR and AR following PAD may be useful for the clinical evaluation of these patients.
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