4.5 Article

Relationship of brain edema after deep brain stimulation surgery with motor and cognitive function

期刊

HELIYON
卷 8, 期 2, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2022.e08900

关键词

Parkinson's disease; Deep brain stimulation; Brain oedema; Magnetic resonance imaging; Micro lesion effect; Subthalamic nucleus

资金

  1. JSPS KAKENHI [JP19K17031]
  2. Research Funding of Longevity Sciences [19-24]
  3. Research on Policy Planning and Evaluation for Rare and Intractable Disease, Ministry of Health, Labour and Welfare [H30-006]

向作者/读者索取更多资源

Research suggests that post-DBS frontal subcortical edema may lead to transient cognitive decline, while peri-STN edema may impact motor function and reduce the need for tuning.
Background: Some patients with Parkinson's disease (PD) develop peri-lead brain edema after deep brain stimulation (DBS) surgery. The influence of edema on neurological function is not well characterized. We investigated the relationship of brain edema after DBS surgery with motor and cognitive function. Methods: Thirteen patients with PD (6 males and 7 females; mean age: 61.2 years) who underwent bilateral subthalamic nucleus (STN) DBS surgery were included. All patients underwent magnetic resonance imaging (MRI) examination on day 6 post-DBS surgery. The volume of edema was measured either in the frontal white matter or STN on fluid attenuated inversion recovery (FLAIR) images. We examined the relationship between these volumes and changes in cognitive and motor function. Results: Patients were divided into those with frontal subcortical edema (FE) >= 3,000 mm(3) (FE thorn group; n = 7) and <3,000 mm(3) (FE-group; n = 6). In the FE + group, the postoperative Mini-Mental State Examination score worsened by 2.4 points after one week compared with that immediately before surgery, while that in the FE-group worsened only by 0.2 points (p = 0.038). On comparing patients with peri-STN edema (SE) >= 1,000 mm(3) (SE + thorngroup; n 3) and those with SE < 1,000 mm(3) (SE-group; n = 10) showed that frequency of DBS tuning in the early postoperative period of the SE + group was lesser than that in the SE-group. Conclusions: Development of FE after DBS surgery was related to transient cognitive decline. On the other hand, SE seemed associated with altered motor function and reduces the requirement for tuning in the initial period after DBS implantation.

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