期刊
MATERIALS TODAY BIO
卷 13, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtbio.2021.100197
关键词
Nanomaterials; Fenton reaction; Chemodynamic therapy; Photothermal therapy; Combination therapy
资金
- National Research Foundation (NRF) of Korea - Ministry of Science, ICT & Future Planning [2016R1D1A3B02011756]
- Ministry of Science, ICT, and Future Planning (MSIP), Korea under the Information Technology Research Center (ITRC) support program [IITP-2016-H8601-16-1011]
- National Research Foundation of Korea (NRF) - Korean government Ministry of Science and ICT (MSIT) [2014K1A1A2043032]
- Korea Institute of Energy Technology Evaluation and Planning (KETEP)
- Ministry of Trade, Industry & Energy (MOTIE) of the Republic of Korea [20142020200980, 20182010600430]
- Korean Ministry of Education, Science Technology [2016R1D1A3B0201175615]
- Grand Information Technology Research Center Program through the Institute of Information & Communications Technology Planning & Evaluation (IITP) - Ministry of Science and ICT (MSIT), Korea [IITP-2021-2020-0-01612]
- King Khalid University, Abha, Saudi Arabia [RGP:1/275/1442]
- Korea Evaluation Institute of Industrial Technology (KEIT) [20142020200980] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2016R1D1A3B02011756] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
PT-enhanced Fenton-based CDT is a promising cancer treatment approach that triggers the Fenton or Fenton-like reactions within the tumor microenvironment to generate highly cytotoxic hydroxyl radicals. However, existing CDT therapies are hindered by limitations such as low levels of endogenous hydrogen peroxide and low catalytic efficacy, prompting the combination of photothermal therapy (PTT) to enhance therapeutic efficacy.
Photothermal (PT)-enhanced Fenton-based chemodynamic therapy (CDT) has attracted a significant amount of research attention over the last five years as a highly effective, safe, and tumor-specific nanomedicine-based therapy. CDT is a new emerging nanocatalyst-based therapeutic strategy for the in situ treatment of tumors via the Fenton reaction or Fenton-like reaction, which has got fast progress in recent years because of its high specificity and activation by endogenous substances. A variety of multifunctional nanomaterials such as metal-, metal oxide-, and metal-sulfide-based nanocatalysts have been designed and constructed to trigger the in situ Fenton or Fentonlike reaction within the tumor microenvironment (TME) to generate highly cytotoxic hydroxyl radicals (center dot OH), which is highly efficient for the killing of tumor cells. However, research is still required to enhance the curative outcomes and minimize its side effects. Specifically, the therapeutic efficiency of certain CDTs is still hindered by the TME, including low levels of endogenous hydrogen peroxide (H2O2), overexpression of reduced glutathione (GSH), and low catalytic efficacy of Fenton or Fenton-like reactions (pH 5.6-6.8), which makes it difficult to completely cure cancer using monotherapy. For this reason, photothermal therapy (PTT) has been utilized in combination with CDT to enhance therapeutic efficacy. More interestingly, tumor heating during PTT not only causes damage to the tumor cells but can also accelerate the generation of center dot OH via the Fenton and Fenton-like reactions, thus enhancing the CDT efficacy, providing more effective cancer treatment when compared with monotherapy. Currently, synergistic PT-enhanced CDT using multifunctional nanomaterials with both PT and chemodynamic properties has made enormous progress in cancer theranostics. However, there has been no comprehensive review on this subject published to date. In this review, we first summarize the recent progress in PT-enhanced Fenton-based CDT for cancer treatment. We then discuss the potential and challenges in the future development of PT-enhanced Fenton-based nanocatalytic tumor therapy for clinical application.
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