4.4 Article

Repository Corticotropin Injection (Acthar(R) Gel) for Refractory Severe Noninfectious Keratitis: Efficacy and Safety from a Phase 4, Multicenter, Open-Label Study

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Summary: The study compared the binding and agonistic activity of Acthar Gel and synthetic MCR agonists, finding that Acthar Gel exhibited different activity levels in various MCRs. Specifically, it showed the lowest level of full agonist activity at MC2R, which may result in lower corticosteroid production.

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