4.7 Article

Photodynamic Bubble-Generating Microneedles for Enhanced Transdermal Cancer Therapy

期刊

ACS APPLIED POLYMER MATERIALS
卷 3, 期 12, 页码 6502-6512

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsapm.1c01219

关键词

bubble-generating microneedles; frozen immersion; transdermal drug delivery; sonophoresis; photodynamic therapy

资金

  1. Singapore Agency for Science, Technology and Research (A*STAR) Science and Engineering Research Council Additive Manufacturing for Biological Materials (AMBM) program [A18A8b0059]
  2. City University of Hong Kong [9610472]
  3. General Research Fund (GRF) from the University Grants Committee of Hong Kong (UGC) Research Grant Council (RGC) [9042951, 9043133]
  4. NSFC/RGC Joint Research Scheme [N_CityU118/20]
  5. Singapore Ministry of Health's National Medical Research Council under its Open Fund Individual Research Grant [MOH-OFIRG19may-0009]
  6. Ministry of Education Singapore under its Academic Research Funding Tier 2 [MOE-T2EP30120-0001]

向作者/读者索取更多资源

This research introduces a new technique using the frozen immersion method to load drugs on bubble-generating microneedles, which enhances drug delivery efficiency by producing bubbles to improve drug transportation, combined with sonophoresis to further increase the efficiency of transdermal drug delivery.
Active bubble-generating microneedles ( MNs) upon skin interstitial fluid (ISF) contact facilitate deeper and more efficient delivery of intradermal therapeutics. However, bubble-generating MN platforms are sensitive to moisture, which limits their variety to load various functional drugs. This article presents a frozen immersion method that facilitates both hydrophobic and hydrophilic drug loading onto bubble-generating MNs without compromising both drug and MN properties. The formed bubbles upon ISF contact induce distinct vortex flow that produces a propulsion force to enhance drug transportation. The efficiency of transdermal drug delivery is further enhanced by sonophoresis. The drug delivery efficiency of this platform is first evaluated ex vivo using fresh mouse skins and human keloid tissues. Later, in the tumor-bearing mouse model, the platform enhances the skin penetration of photosensitizers (i.e., methylene blue) and correspondingly improves the efficacy of photodynamic therapy.

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