期刊
NANOSCALE ADVANCES
卷 4, 期 3, 页码 792-800出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1na00791b
关键词
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资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1C1C1011863, 2020R1A5A8017671]
- National Research Foundation of Korea [2020R1A5A8017671, 2020R1C1C1011863] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The mag-spinner system, combining magnets with a spinner system, is a new type of magnetic separation system for biological and medical sample preprocessing. It successfully captures targets quickly and efficiently, meeting the requirements for desirable separation systems.
Mag-spinner, a system in which magnets are combined with a spinner system, is a new type of magnetic separation system for the preprocessing of biological and medical samples. Interference by undesired components restricts the detection accuracy and efficiency. Thus, the development of appropriate separation techniques is required for better detection of the desired targets, to enrich the target analytes and remove the undesired components. The strong response of iron oxide nanoclusters can successfully capture the targets quickly and with high efficiency. As a result, cancer cells can be effectively separated from blood using the developed mag-spinner system. Indeed, this system satisfies the requirements for desirable separation systems, namely (i) fast sorting rates, (ii) high separation efficiency, (iii) the ability to process native biological fluids, (iv) simple operating procedures, (v) low cost, (vi) operational convenience, and (vii) portability. Therefore, this system is widely applicable to sample preparation without limitations on place, cost, and equipment.
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