期刊
ACS APPLIED NANO MATERIALS
卷 4, 期 12, 页码 13510-13522出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.1c02986
关键词
open-mouthed particle; catechin; drug delivery; dye adsorption; benzoxazine; hollow particle
资金
- National Natural Science Foundation of China [31872750, 51373106]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYJC21036]
Polyphenol-based hollow nanoparticles with bowl-shaped structures show promising properties in drug delivery, catalysis, and energy storage due to their improved inner surface accessibility. A novel assembly strategy using a wide selection of polyphenolic compounds, such as tea polyphenols, has been demonstrated in this study to efficiently prepare these nanoparticles with potential applications in active delivery systems, carbon spheres, and anticancer agents. This polyphenol assembly strategy also provides inspiration for further studies on the structure-property-function relationship of polyphenol-based materials.
Polyphenol-based hollow nanoparticles have exhibited intriguing properties in drug delivery, catalysis, and energy storage, and the open-mouthed (bowl-shaped) structure is supposed to improve the performance of the nanoparticles by increasing the accessibility of the inner surface and the cavity. Up to now, cationic polymers, metal ions, and sacrificial templates are generally applied in the preparation of the polyphenol-based hollow nanoparticle, and these polyphenols are usually confined to tannin acid and lignin. Seeking for the novel assembly strategy with a wide selection of polyphenolic compounds would open a new horizon for the design, preparation, and applications of polyphenol-based functional materials. In this study, polyphenol nanoparticles with bowl-shaped structure were efficiently prepared through the polymerization-induced self-assembly of tea polyphenols in a few minutes. The formation mechanism was proposed on the basis of a series of TEM images revealing the morphology evolution process. The nanoparticles with good stability in carbonization process are candidates for bowl-shaped carbon spheres. These nanoparticles exhibit potent radical scavenging capacity, anticancer activity, high adsorption capacity of guest molecules (DOX and methylene blue), and pH-dependent release property, with promising use as active delivery systems. Moreover, the present polyphenol assembly strategy provides inspiration for fundamental studies on structure-property-function relationship of polyphenol-based materials.
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