期刊
ACS APPLIED NANO MATERIALS
卷 5, 期 2, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.1c04428
关键词
ring-opening molecular layer deposition; alumosilazane; alumosiloxane; organosilicon; biocompatible films; human embryonic kidney (HEK293T) cells; thin film; hybrid
资金
- Spanish Ministry of Science and Innovation (MICINN) [PID2019-111065RB-I00]
- Maria de Maeztu Units of Excellence Programme [CEX2020-001038-M]
- European Union [765378]
Silicon-based polymers have great potential for applications in biomedicine, nanotechnology, tissue targeting, and drug delivery. A solvent-free molecular layer deposition (MLD) process has been developed to grow environmentally stable hybrid alumosilazane thin films. These films exhibit exceptional biocompatibility and can be used as functional coatings for scaffolds or implantable devices with complex topologies or high-aspect-ratio structures.
Silicon-based polymers show great promise for various applications in biomedicine, nanotechnology, tissue targeting, and drug deliv e r y . The use of such materials as functional coatings on surfaces requires the development of strongly adhering and flexible conformal films, which is challenging for conventional wet-chemical coating techniques. We have developed a facile, solvent-free molecular layer deposition (MLD) process to grow environmentally stable hybrid alumosilazane thin films. Exceptionally good biocompatibility is testified with significantly higher proliferation of human embryonic kidney (HEK293T) cells than that on glass, which was used as a reference. Such highly biocompatible and conformal films show great promise as functional coatings for scaffolds or implantable devices with complex topologies or high-aspect-ratio structures.
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