期刊
ACS APPLIED NANO MATERIALS
卷 5, 期 1, 页码 1635-1643出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.1c04412
关键词
synergistic catalyst; electrochemical sensor; simultaneous determination; DNA bases; calf thymus DNA
资金
- National Natural Science Foundation of China [21874087]
- Key R&D project of Shanxi Province [201803D421031]
- Graduate Student Education Innovation project [2020BY013]
- Shanxi Scholarship Council of China [2017 Key1]
A reliable and accurate electrochemical sensor based on a gold/palladium-polypyrrole/graphene nanocomposite has been developed for the detection of DNA bases. The sensor exhibits excellent electrocatalytic activity and a wide linear range, and can selectively identify the four bases in calf thymus DNA.
The unique combination of DNA bases is essential for storing genetic information. A reliable and accurate electrochemical sensor based on a gold/palladium-polypyrrole/graphene nanocomposite (Au/Pd-PPy/GR) has been prepared to individually and simultaneously detect guanine (G), adenine (A), thymine (T), and cytosine (C). The bimetallic nanomaterial (Au/Pd-PPy) is used to enhance the sensing performance of DNA bases, and the GR could further increase the electroactive area and amplify the electrochemical response. As expected, the electrochemical sensor shows excellent electrocatalytic activity with well-separated current responses at 0.704 V (G), 0.976 (A), 1.164 (T), and 1.348 V (C). The prepared sensor exhibits the linear range of 1-350 mu M for G, 5-300 mu M for A, 20-900 mu M for T, and 10-700 mu M for C. The developed device is also demonstrated as an excellently sensitive and highly selective sensor to identify the four bases in calf thymus DNA, which provides the application of electrochemical sensors in bioscience.
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