期刊
PHARMACOLOGY RESEARCH & PERSPECTIVES
卷 10, 期 1, 页码 -出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/prp2.917
关键词
ACE2; COVID-19; inflammation; renin-angiotensin-aldosterone system; therapies
Interaction between SARS-CoV-2 and its receptor ACE2 leads to an uncontrolled inflammatory response, resulting in the pathogenesis of COVID-19. The renin-angiotensin system plays a crucial role in the host response to infection and injury, and disruption of ACE2 by SARS-CoV-2 leads to tissue damage.
SARS-CoV-2 interacting with its receptor, angiotensin-converting enzyme 2 (ACE2), turns the host response to viral infection into a dysregulated uncontrolled inflammatory response. This is because ACE2 limits the production of the peptide angiotensin II (Ang II) and SARS-CoV-2, through the destruction of ACE2, allows the uncontrolled production of Ang II. Recovery from trauma requires activation of both a tissue response to injury and activation of a whole-body response to maintain tissue perfusion. Tissue and circulating renin-angiotensin systems (RASs) play an essential role in the host response to infection and injury because of the actions of Ang II, mediated via its AT(1) receptor. Both tissue and circulating arms of the renin angiotensin aldosterone system's (RAAS) response to injury need to be regulated. The effects of Ang II and the steroid hormone, aldosterone, on fluid and electrolyte homeostasis and on the circulation are controlled by elaborate feedback networks that respond to alterations in the composition and volume of fluids within the circulatory system. The role of Ang II in the tissue response to injury is however, controlled mainly by its metabolism and conversion to Ang-(1-7) by the enzyme ACE2. Ang-(1-7) has effects that are contrary to Ang II-AT(1)R mediated effects. Thus, destruction of ACE2 by SARS-CoV-2 results in loss of control of the pro-inflammatory actions of Ang II and tissue destruction. Therefore, it is the response of the host to SARS-CoV-2 that is responsible for the pathogenesis of COVID-19.
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