4.3 Review

Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents

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Summary: Motilin, produced in the upper intestine, acts as an important regulator of gastrointestinal motility and mediates the phase III of interdigestive migrating motor complex in the stomach of humans, dogs, and musk shrews. It helps maintain normal GI functions and transmits hunger signals from the stomach to the brain. The structure, distribution, receptor, and regulatory function of motilin vary among vertebrates from fish to mammals.

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