Comparison of COVID-19 outcomes in organ transplant recipients (OTr) and non-transplant patients: a study protocol for rapid review

Article Health Care Sciences & Services

Cochrane Rapid Reviews Methods Group offers evidence-informed guidance to conduct rapid reviews

Chantelle Garritty et al.

Summary: The study aims to develop guidance to support the conduct of rapid reviews, with 26 recommendations presented based on survey results. These recommendations will help synthesize evidence for urgent health issues, but the guidance will need to be updated as new evaluations for some RR methods are conducted due to the current lack of available evidence.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Article Immunology

COVID-19 Outcomes Among Solid Organ Transplant Recipients: A Case-control Study

Pratima Sharma et al.

Summary: Solid organ transplant recipients are vulnerable to COVID-19 infection due to immunosuppression. This study compared the outcomes of COVID-19 between SOT recipients and their matched nontransplant controls, finding similar rates of severe disease and short-term death but higher risk for renal replacement therapy in SOT patients. Hydroxychloroquine treatment for COVID-19 in SOT recipients was associated with high mortality, warranting further scrutiny of its role as a treatment modality.

TRANSPLANTATION (2021)

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Article Surgery

Is COVID-19 infection more severe in kidney transplant recipients?

Sophie Caillard et al.

Summary: Transplant recipients had a higher COVID-19-related mortality compared to nontransplant hospitalized patients but did not differ significantly in the rate of severe disease. Factors associated with severe COVID-19 included age, cardiovascular disease, dyspnea, fever, lymphopenia, and CRP.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Review Immunology

COVID-19 in solid organ transplant recipients: A systematic review and meta-analysis of current literature

Mohammed A. Raja et al.

Summary: A systematic review and meta-analysis of SOT recipients with SARS-CoV-2 infection revealed a high hospital admission rate and mortality rate. Common symptoms included fever and cough, with the majority of recipients requiring hospital treatment. Use of immunosuppressive medications decreased, while treatments varied.

TRANSPLANTATION REVIEWS (2021)

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Review Immunology

Effect of immunosuppression maintenance in solid organ transplant recipients with COVID-19: Systematic review and meta-analysis

Arta Karruli et al.

Summary: The study suggests that continuing immune suppression in SOTR with COVID-19 may be safe and beneficial, especially with tacrolimus. Age and specific drug use were predictors of mortality, while immune suppression maintenance and tacrolimus continuation were predictors of survival.

TRANSPLANT INFECTIOUS DISEASE (2021)

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Article Medicine, General & Internal

Validity of observational evidence on putative risk and protective factors: appraisal of 3744 meta-analyses on 57 topics

Perrine Janiaud et al.

Summary: This study evaluated thousands of meta-analyses of observational studies and found that while most associations were statistically significant, few were convincing and corroborated by randomized evidence. Across different topics, there was large heterogeneity in the proportion of associations meeting various quantitative criteria, which were mostly independent of each other.

BMC MEDICINE (2021)

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Article Medicine, General & Internal