期刊
IMMUNITY INFLAMMATION AND DISEASE
卷 10, 期 2, 页码 189-200出版社
WILEY
DOI: 10.1002/iid3.560
关键词
adolescent; asthma; biomarker; child; surfactant protein D
类别
资金
- AP Moller Foundation for the Advancement of Medical Science
- Bornelungefonden
- Claus Peter Christensen's Memorial Trust
- Sven Hansen og Hustru Ina Hansens Foundation
- Research council of the Region of Southern Denmark [R22-A1227]
This study found no association between serum surfactant protein D levels, common SP-D gene variants, and asthma in Danish adolescents and young adults with mild to moderate asthma. Serum surfactant protein D did not show value as a clinical biomarker for asthma.
Background: Surfactant Protein D (SP-D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP-D levels in bronchoalveolar lavage samples decrease and serum levels increase in patients suffering from asthma, possibly due to a combination of induced SP-D synthesis and decreased air-blood barrier integrity. The aims of this study were to investigate whether serum levels of SP-D and common variants in the SP-D gene were associated with asthma in adolescents and young adults. Methods: Prospective observational study including 449 adolescents and young adults (age 11-27 years) previously diagnosed with asthma during a 2-year period from 2003 to 2005 (0-16 years). At follow-up from 2016 to 2017, 314 healthy controls with no history of asthma were recruited. Serum SP-D was analyzed on samples obtained at baseline as well as samples obtained at followup. SP-D genotyping was performed for rs721917, rs2243639, and rs3088308. Results: No differences were found in mean levels of sSP-D and SFTPD genotype among subjects with current asthma, no current asthma, and controls. Serum SP-D and SFTPD genotype were not associated with any clinical parameters of asthma. Furthermore, baseline sSP-D was not associated with asthma at follow-up. Conclusion: Serum surfactant protein D and common SP-D gene variants were not associated with asthma in Danish adolescents and young adults with mild to moderate asthma. Serum surfactant protein D did not demonstrate any value as a clinical biomarker of asthma.
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