期刊
LIFE-BASEL
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/life11101074
关键词
PRMT5; cancer; cardiovascular disease; neurodegenerative diseases; diabetes; inflammation
资金
- NIH-NIGMS [1R01GM120156-01A1]
As research on PRMT5's role in diseases progresses, it has been found to play crucial roles in many important biological functions. Its involvement in cancer and inflammatory diseases is well-documented, highlighting the importance of developing better treatment strategies.
Since the discovery of protein arginine methyltransferase 5 (PRMT5) and the resolution of its structure, an increasing number of papers have investigated and delineated the structural and functional role of PRMT5 in diseased conditions. PRMT5 is a type II arginine methyltransferase that catalyzes symmetric dimethylation marks on histones and non-histone proteins. From gene regulation to human development, PRMT5 is involved in many vital biological functions in humans. The role of PRMT5 in various cancers is particularly well-documented, and investigations into the development of better PRMT5 inhibitors to promote tumor regression are ongoing. Notably, emerging studies have demonstrated the pathological contribution of PRMT5 in the progression of inflammatory diseases, such as diabetes, cardiovascular diseases, and neurodegenerative disorders. However, more research in this direction is needed. Herein, we critically review the position of PRMT5 in current literature, including its structure, mechanism of action, regulation, physiological and pathological relevance, and therapeutic strategies.
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