The Roles of Neurotrophins in Traumatic Brain Injury

Neurotrophins are a collection of structurally and functionally related proteins. They play important roles in many aspects of neural development, survival, and plasticity. Traumatic brain injury (TBI) leads to different levels of central nervous tissue destruction and cellular repair through various compensatory mechanisms promoted by the injured brain. Many studies have shown that neurotrophins are key modulators of neuroinflammation, apoptosis, blood-brain barrier permeability, memory capacity, and neurite regeneration. The expression of neurotrophins following TBI is affected by the severity of injury, genetic polymorphism, and different post-traumatic time points. Emerging research is focused on the potential therapeutic applications of neurotrophins in managing TBI. We conducted a comprehensive review by organizing the studies that demonstrate the role of neurotrophins in the management of TBI.

Automated summary

Neurotrophins play crucial roles in neural development, survival, and plasticity, and are key regulators of neuroinflammation, apoptosis, memory capacity, and neurite regeneration following traumatic brain injury. The expression of neurotrophins post-TBI is influenced by injury severity, genetic polymorphism, and timing of trauma. Emerging research is exploring the therapeutic potential of neurotrophins in managing TBI.