期刊
LIFE-BASEL
卷 11, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/life11121301
关键词
NAD(P)H; quinone oxidoreductase 1; oxidative stress; human diseases
资金
- Chung-Ang University Research Scholarship Grants 2020
- Basic Science Research Program through the National Research Foundation of Korea [2020R1A2C1009647]
- National Research Foundation of Korea [2020R1A2C1009647] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
NQO1 is an antioxidant flavoprotein that exerts antioxidant activities, anti-inflammatory effects, and interacts with tumor suppressors. Recent studies have highlighted the promising roles of NQO1 in protecting against cardiovascular damage and related diseases.
NAD(P)H:quinone oxidoreductase (NQO) is an antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites by employing NAD(P)H as an electron donor. There are two NQO enzymes-NQO1 and NQO2-in mammalian systems. In particular, NQO1 exerts many biological activities, including antioxidant activities, anti-inflammatory effects, and interactions with tumor suppressors. Moreover, several recent studies have revealed the promising roles of NQO1 in protecting against cardiovascular damage and related diseases, such as dyslipidemia, atherosclerosis, insulin resistance, and metabolic syndrome. In this review, we discuss recent developments in the molecular regulation and biochemical properties of NQO1, and describe the potential beneficial roles of NQO1 in diseases associated with oxidative stress.
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