期刊
LIFE-BASEL
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/life12020234
关键词
psoriasis; antigen-presenting cells; autoantigens; keratinocyte; mast cell; neuropeptide
资金
- National Research, Development and Innovation Office of Hungary [FK134588, K123975, FK134993]
- University of Debrecen
- Thematic Excellence Program [TKP2021-EGA-19, TKP2021-EGA-20]
- Ministry for Innovation and Technology in Hungary
This review discusses the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during the initiation and onset of psoriasis.
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and sustaining inflammation under pathologic conditions. In this review we discuss the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during psoriasis initiation and onset.
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