4.6 Review

Microfluidic Platforms to Unravel Mysteries of Alzheimer's Disease: How Far Have We Come?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Neurosciences

Critical Review of the Alzheimer's Disease Non-Transgenic Models: Can They Contribute to Disease Treatment?

Julio A. Flores-Cuadra et al.

Summary: Alzheimer's disease is a growing neurodegenerative disease without effective treatments, characterized by amyloid-beta plaques, neurofibrillary tangles, and neuroinflammatory processes. While research has focused on amyloid-based models, non-transgenic models may offer complementary alternatives for understanding complex pathological states. This review emphasizes the need for a shift in preclinical research towards non-amyloid approaches for AD intervention strategies.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Clinical Neurology

2021 Alzheimer's disease facts and figures

[Anonymous]

Summary: Alzheimer's disease has a significant impact on individuals and society as a whole, with a large number of patients in the United States and a potential for continued growth in the future. The value of unpaid caregivers has increased despite a decline in their numbers, and healthcare costs are on the rise. Racial and ethnic disparities in healthcare persist, highlighting the need for greater diversity in dementia care workforce and clinical trials.

ALZHEIMERS & DEMENTIA (2021)

Review Chemistry, Analytical

Actuation Mechanism of Microvalves: A Review

Jin-Yuan Qian et al.

MICROMACHINES (2020)

Review Geriatrics & Gerontology

Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer's Disease

Qingqing Yin et al.

CLINICAL INTERVENTIONS IN AGING (2020)

Review Biochemistry & Molecular Biology

Biochemical Markers in Alzheimer's Disease

Alessandro Rabbito et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Chemistry, Multidisciplinary

Early Diagnosis of Alzheimer's Disease in Blood Using a Disposable Electrochemical Microfluidic Platform

Tassia R. de Oliveira et al.

ACS SENSORS (2020)

Article Biochemistry & Molecular Biology

Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures

Antigoni Katsikoudi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies

Maria Ines Teixeira et al.

PHARMACEUTICS (2020)

Review Health Care Sciences & Services

New Insights into the Molecular Bases of Familial Alzheimer's Disease

Valeria D'Argenio et al.

JOURNAL OF PERSONALIZED MEDICINE (2020)

Review Neurosciences

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

Tiantian Guo et al.

MOLECULAR NEURODEGENERATION (2020)

Article Clinical Neurology

World Alzheimer Report 2019: Attitudes to dementia, a global survey

Chris Lynch

Alzheimers & Dementia (2020)

Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Editorial Material Health Care Sciences & Services

Biomarkers for Alzheimer's Disease: Where Do We Stand and Where Are We Going?

Chiara Villa

JOURNAL OF PERSONALIZED MEDICINE (2020)

Review Cell Biology

Microfluidics as an Emerging Precision Tool in Developmental Biology

Katharina F. Sonnen et al.

DEVELOPMENTAL CELL (2019)

Review Biochemistry & Molecular Biology

Nuclear factor-kappa β as a therapeutic target for Alzheimer's disease

Niraj Kumar Jha et al.

JOURNAL OF NEUROCHEMISTRY (2019)

Article Multidisciplinary Sciences

Paper-based microfluidics for DNA diagnostics of malaria in low resource underserved rural communities

Julien Reboud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

Review Geriatrics & Gerontology

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease

Celia G. Fernandez et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Neurosciences

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

Yingjian You et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers

Jinny Claire Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Review Neurosciences

The neuropathological diagnosis of Alzheimer's disease

Michael A. DeTure et al.

MOLECULAR NEURODEGENERATION (2019)

Article Chemistry, Multidisciplinary

Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

Yoojin Shin et al.

ADVANCED SCIENCE (2019)

Editorial Material Biochemistry & Molecular Biology

Brain organoids: a next step for humanized Alzheimer's disease models?

Yannis Gerakis et al.

MOLECULAR PSYCHIATRY (2019)

Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Engineering, Biomedical

In Vitro Microfluidic Models for Neurodegenerative Disorders

Tatsuya Osaki et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Engineering, Biomedical

Three-Dimensional Models of the Human Brain Development and Diseases

Mehdi Jorfi et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Clinical Neurology

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Maitrayee Sardar Sinha et al.

ACTA NEUROPATHOLOGICA (2018)

Article Neurosciences

Implantable, wireless device platforms for neuroscience research

Philipp Gutruf et al.

CURRENT OPINION IN NEUROBIOLOGY (2018)

Review Biochemistry & Molecular Biology

Liquid Marbles: From Industrial to Medical Applications

Roxana-Elena Avramescu et al.

MOLECULES (2018)

Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

Review Neurosciences

Animal models of neurodegenerative diseases

Ted M. Dawson et al.

NATURE NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Collin D. Edington et al.

SCIENTIFIC REPORTS (2018)

Article Nanoscience & Nanotechnology

Cryoprotectant-Free Freezing of Cells Using Liquid Marbles Filled with Hydrogel

Raja Vadivelu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Biochemical Research Methods

Disposable silicon-glass microfluidic devices: precise, robust and cheap

ZhenBang Qi et al.

LAB ON A CHIP (2018)

Review Biochemistry & Molecular Biology

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer's Disease

Yu Yamazaki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Cell Biology

Aberrant iPSC-derived human astrocytes in Alzheimer's disease

V. C. Jones et al.

CELL DEATH & DISEASE (2017)

Article Neurosciences

Alzheimer's Disease and the Amyloid-β Peptide

M. Paul Murphy et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind

Roberta Ricciarelli et al.

CURRENT NEUROPHARMACOLOGY (2017)

Review Engineering, Mechanical

Digital microfluidics: A promising technique for biochemical applications

He Wang et al.

FRONTIERS OF MECHANICAL ENGINEERING (2017)

Review Clinical Neurology

Targeting Neuroinflammation to Treat Alzheimer's Disease

A. Ardura-Fabregat et al.

CNS DRUGS (2017)

Review Biochemical Research Methods

Advances in microfluidic devices made from thermoplastics used in cell biology and analyses

Elif Gencturk et al.

BIOMICROFLUIDICS (2017)

Review Medicine, Research & Experimental

Experimental models of Alzheimer's disease for deciphering the pathogenesis and therapeutic screening (Review)

Xueyuan Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Review Clinical Neurology

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

Valeria Calsolaro et al.

ALZHEIMERS & DEMENTIA (2016)

Review Biotechnology & Applied Microbiology

Advances in microfluidics in combating infectious diseases

Andy Tay et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Biochemistry & Molecular Biology

Exosomes in the Pathology of Neurodegenerative Diseases

Jason Howitt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Endocrinology & Metabolism

Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers

Ralf G. Rempe et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)

Review Biochemical Research Methods

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

Nachiket Shembekar et al.

LAB ON A CHIP (2016)

Review Biochemical Research Methods

The upcoming 3D-printing revolution in microfluidics

Nirveek Bhattacharjee et al.

LAB ON A CHIP (2016)

Review Clinical Neurology

Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers

Alexander G. Thompson et al.

NATURE REVIEWS NEUROLOGY (2016)

Review Chemistry, Multidisciplinary

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

Fuyin Zheng et al.

Article Multidisciplinary Sciences

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

Karen E. Marshall et al.

SCIENTIFIC REPORTS (2016)

Review Medicine, General & Internal

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

Urmi Sengupta et al.

EBIOMEDICINE (2016)

Article Biochemical Research Methods

Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability

J. I. Forster et al.

JOURNAL OF BIOMOLECULAR SCREENING (2016)

Review Biotechnology & Applied Microbiology

Microfluidics-based 3D cell culture models: Utility in novel drug discovery and delivery research

Nilesh Gupta et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2016)

Review Biochemical Research Methods

Microfluidics-to-mass spectrometry: A review of coupling methods and applications

Xue Wang et al.

JOURNAL OF CHROMATOGRAPHY A (2015)

Review Engineering, Electrical & Electronic

Mixing in microfluidic devices and enhancement methods

Kevin Ward et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2015)

Article Biotechnology & Applied Microbiology

Organs-on-chips at the frontiers of drug discovery

Eric W. Esch et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Review Biochemical Research Methods

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

Rasheena Edmondson et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2014)

Review Biochemical Research Methods

Human-on-chip for therapy development and fundamental science

Camilla Luni et al.

CURRENT OPINION IN BIOTECHNOLOGY (2014)

Article Biochemistry & Molecular Biology

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

Christina R. Muratore et al.

HUMAN MOLECULAR GENETICS (2014)

Article Cell Biology

Sensory neurons and osteoblasts: close partners in a microfluidic platform

Estrela Neto et al.

INTEGRATIVE BIOLOGY (2014)

Article Neurosciences

Circulating miRNAs as Potential Biomarkers in Alzheimer's Disease

Daniela Galimberti et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Review Cell & Tissue Engineering

Concise Review: Modeling Central Nervous System Diseases Using Induced Pluripotent Stem Cells

Xianmin Zeng et al.

STEM CELLS TRANSLATIONAL MEDICINE (2014)

Review Biotechnology & Applied Microbiology

Microfluidic chip-based technologies: emerging platforms for cancer diagnosis

Li Ying et al.

BMC BIOTECHNOLOGY (2013)

Review Pharmacology & Pharmacy

Three-dimensional cell culture: the missing link in drug discovery

Susan Breslin et al.

DRUG DISCOVERY TODAY (2013)

Article Biochemical Research Methods

Microfluidic-primary culture model of the lower motor neuron-neuromuscular junction circuit

Katherine A. Southam et al.

JOURNAL OF NEUROSCIENCE METHODS (2013)

Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Chia-Chan Liu et al.

NATURE REVIEWS NEUROLOGY (2013)

Review Neurosciences

Biomarker Modeling of Alzheimer's Disease

Clifford R. Jack et al.

NEURON (2013)

Article Multidisciplinary Sciences

Synapto-Protective Drugs Evaluation in Reconstructed Neuronal Network

Berangere Deleglise et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Probing Functional Properties of Nociceptive Axons Using a Microfluidic Culture System

Christoforos Tsantoulas et al.

PLOS ONE (2013)

Review Pharmacology & Pharmacy

Modeling Alzheimer's disease: from past to future

Claudia Saraceno et al.

FRONTIERS IN PHARMACOLOGY (2013)

Review Clinical Neurology

Current and future treatments for Alzheimer's disease

Konstantina G. Yiannopoulou et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2013)

Article Biochemical Research Methods

A perspective on paper-based microfluidics: Current status and future trends

Xu Li et al.

BIOMICROFLUIDICS (2012)

Article Biochemical Research Methods

Polyurethane-based microfluidic devices for blood contacting applications

Wen-I Wu et al.

LAB ON A CHIP (2012)

Article Multidisciplinary Sciences

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

Mason A. Israel et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Anja Kunze et al.

BIOTECHNOLOGY AND BIOENGINEERING (2011)

Article Geriatrics & Gerontology

A Blood-Based Algorithm for the Detection of Alzheimer's Disease

Sid E. O'Bryant et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2011)

Article Engineering, Electrical & Electronic

Hot embossing of plastic microfluidic devices using poly(dimethylsiloxane) molds

Vasiliy N. Goral et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2011)

Article Chemistry, Multidisciplinary

Microfluidic Biosensor for β-Amyloid(1-42) Detection Using Cyclic Voltammetry

Kamrul Islam et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2011)

Article Biochemical Research Methods

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

Jean-Michel Peyrin et al.

LAB ON A CHIP (2011)

Article Biochemistry & Molecular Biology

Microfluidics-based diagnostics of infectious diseases in the developing world

Curtis D. Chin et al.

NATURE MEDICINE (2011)

Article Geriatrics & Gerontology

β-Amyloid impairs axonal BDNF retrograde trafficking

Wayne W. Poon et al.

NEUROBIOLOGY OF AGING (2011)

Article Multidisciplinary Sciences

Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites

Michael S. Cohen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Cell Biology

Alzheimer's Disease: The Challenge of the Second Century

David M. Holtzman et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Chemistry, Multidisciplinary

Adsorption of proteins to thin-films of PDMS and its effect on the adhesion of human endothelial cells

Karin Y. Chumbimuni-Torres et al.

RSC ADVANCES (2011)

Article Engineering, Biomedical

Microfluidic dissociation and clearance of Alzheimer's β-amyloid aggregates

Joon Seok Lee et al.

BIOMATERIALS (2010)

Article Biochemical Research Methods

Fabrication of microfluidic devices using polydimethylsiloxane

James Friend et al.

BIOMICROFLUIDICS (2010)

Article Neurosciences

Microglia and Inflammation in Alzheimer's Disease

Shweta Mandrekar-Colucci et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)

Article Biochemical Research Methods

Circular compartmentalized microfluidic platform: Study of axon-glia interactions

Suneil Hosmane et al.

LAB ON A CHIP (2010)

Review Chemistry, Multidisciplinary

Microfluidic tools for cell biological research

Guilhem Velve-Casquillas et al.

NANO TODAY (2010)

Article Biochemistry & Molecular Biology

Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells

Li Zhang et al.

NEUROCHEMISTRY INTERNATIONAL (2010)

Article Engineering, Biomedical

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

Jaewon Park et al.

BIOMEDICAL MICRODEVICES (2009)

Article Biotechnology & Applied Microbiology

Neurite Growth in 3D Collagen Gels With Gradients of Mechanical Properties

Harini G. Sundararaghavan et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Biochemistry & Molecular Biology

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

Will Stoothoff et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Neurosciences

Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice

Kelly R. Bales et al.

JOURNAL OF NEUROSCIENCE (2009)

Review Genetics & Heredity

Genetic aspects of Alzheimer disease

Thomas D. Bird

GENETICS IN MEDICINE (2008)

Review Biochemical Research Methods

Cell research with physically modified microfluidic channels: A review

Sun Min Kim et al.

LAB ON A CHIP (2008)

Review Clinical Neurology

Amyloid-beta immunisation for Alzheimer's disease

Thomas Wisniewski et al.

LANCET NEUROLOGY (2008)

Article Biochemistry & Molecular Biology

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

Sandip Ray et al.

NATURE MEDICINE (2007)

Article Biochemical Research Methods

Stripe assay to examine axonal guidance and cell migration

Bernd Knoell et al.

NATURE PROTOCOLS (2007)

Review Neurosciences

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

Carlo Ballatore et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Review Multidisciplinary Sciences

A century of Alzheimer's disease

Michel Goedert et al.

SCIENCE (2006)

Review Biotechnology & Applied Microbiology

Lab-on-a-chip: microfluidics in drug discovery

PS Dittrich et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Biochemistry & Molecular Biology

Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

RE Tanzi et al.

Letter Medicine, General & Internal

Cholinesterase inhibitors for Alzheimer disease

S Lilienfeld

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Article Chemistry, Multidisciplinary

Microfluidic multicompartment device for neuroscience research

AM Taylor et al.

LANGMUIR (2003)

Review Chemistry, Multidisciplinary

Poly(dimethylsiloxane) as a material for fabricating microfluidic devices

JC McDonald et al.

ACCOUNTS OF CHEMICAL RESEARCH (2002)

Article Engineering, Electrical & Electronic

PDMS-based microfluidic devices for biomedical applications

T Fujii

MICROELECTRONIC ENGINEERING (2002)