期刊
LIFE-BASEL
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/life12010104
关键词
GK rat; diabetes; redox metabolism; mitochondrial bioenergetics; aspirin; CYP 450s
资金
- Sheikh Hamdan Bin Rashid Al Maktoum Award (HR) for Medical Sciences [MRG-01/2011-2012]
- Research Committee College of Medicine and Health Sciences [NP-14/01, NP-20/13]
- UAE University, UAE
Aspirin treatment prevents alterations in mitochondrial function, improves pancreatic endocrine function, and regulates oxidative metabolism. It also improves respiratory function and energy metabolism in mitochondria, and repairs some cellular abnormalities in the liver and kidneys.
Our recent studies have demonstrated that aspirin treatment prevents inflammatory and oxidative stress-induced alterations in mitochondrial function, improves glucose tolerance and pancreatic endocrine function and preserves tissue-specific glutathione (GSH)-dependent redox homeostasis in Goto-Kakizaki (GK) diabetic rats. In the current study, we have investigated the mechanism of action of aspirin in maintaining mitochondrial bioenergetics and redox metabolism in the liver and kidneys of GK rats. Aspirin reduced the production of reactive oxygen species (ROS) and oxidative stress-induced changes in GSH metabolism. Aspirin treatment also improved mitochondrial respiratory function and energy metabolism, in addition to regulating the expression of cell signaling proteins that were altered in diabetic animals. Ultrastructural electron microscopy studies revealed decreased accumulation of glycogen in the liver of aspirin-treated diabetic rats. Hypertrophic podocytes with irregular fusion of foot processes in the renal glomerulus and detached microvilli, condensed nuclei and degenerated mitochondria observed in the proximal convoluted tubules of GK rats were partially restored by aspirin. These results provide additional evidence to support our previous observation of moderation of diabetic complications by aspirin treatment in GK rats and may have implications for cautious use of aspirin in the therapeutic management of diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据