期刊
MEMBRANES
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/membranes12020203
关键词
porous mixed matrix membrane adsorbers; uremic toxins; urea; zeolite; activated carbon; water purification; dialysis
类别
资金
- Italian National Ministry of University and Research
- RSE Saltire Facilitation Workshop Award 1898 Susmedia: -Engineering membrane adsorbers for sustainable dialysis
Mixed Matrix Membrane Adsorbers (MMMA) have been developed to remove urea, creatinine, and uric acid from dialysate water in order to reduce water consumption and enable the development of closed-loop hemodialysis devices.
We developed Mixed Matrix Membrane Adsorbers (MMMAs) formed by cellulose acetate and various sorbent particles (activated carbon, zeolites ZSM-5 and clinoptilolite) for the removal of urea, creatinine and uric acid from aqueous solutions, to be used in the regeneration of spent dialysate water from Hemodialysis (HD). This process would allow reducing the disproportionate amount of water consumed and permits the development of closed-loop HD devices, such as wearable artificial kidneys. The strategy of MMMAs is to combine the high permeability of porous membranes with the toxin-capturing ability of embedded particles. The water permeability of the MMMAs ranges between 600 and 1500 L/(h m(2) bar). The adsorption of urea, the limiting toxin, can be improved of about nine times with respect to the pure cellulose acetate membrane. Flow experiments demonstrate the feasibility of the process in a real HD therapy session.
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