4.5 Review

Dual-Specificity Phosphatases and Kidney Diseases

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Review Neurosciences

Dual-specificity phosphatases in mental and neurological disorders

Ning An et al.

Summary: The DUSP family of genes consists of heterogeneous protein phosphatases that can dephosphorylate various substrates, modulating neural functions and being associated with mental and neurological disorders. This review outlines the structure and functions of DUSP genes, provides an overview of their role in mental and neurological disorders, and offers perspectives for future research.

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miR-122-5p suppresses the oncogenesis of PTC by inhibiting DUSP4 expression

Ning Hu et al.

Summary: miR-122-5p plays a crucial role in regulating the occurrence and development of papillary thyroid carcinoma (PTC) by inhibiting the tumor-promoting gene DUSP4, thereby suppressing the proliferation and metastasis of PTC cells, revealing its potential diagnostic and therapeutic value in PTC.

MOLECULAR MEDICINE REPORTS (2021)

Article Biochemistry & Molecular Biology

DUSP1 overexpression attenuates renal tubular mitochondrial dysfunction by restoring Parkin-mediated mitophagy in diabetic nephropathy

Chang Lu et al.

Summary: The study showed that DUSP1 partially restored autophagic flux, improved mitochondrial function, and reduced reactive oxygen species generation and cell apoptosis under high-glucose conditions. By restoring parkin-mediated mitophagy, DUSP1 may be considered a potential therapeutic strategy for treating DN.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Cell Biology

Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure

Michael Mutlak et al.

Summary: Pressure overload and other stress stimuli lead to cardiac hypertrophy and heart failure through signaling cascades, with MAPK pathway and DUSPs playing important roles.

CELLULAR SIGNALLING (2021)

Article Oncology

DUSP6 protects murine podocytes from high glucose-induced inflammation and apoptosis

Liqiang Chen et al.

MOLECULAR MEDICINE REPORTS (2020)

Article Cell Biology

DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways

Junqin Sheng et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

MAPK/ERK Signaling in Regulation of Renal Differentiation

Kristen Kurtzeborn et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability

Hsueh-Fen Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Pharmacology & Pharmacy

Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury

Chao Zhang et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Article Biochemistry & Molecular Biology

DUSP26 regulates podocyte oxidative stress and fibrosis in a mouse model with diabetic nephropathy through the mediation of ROS

Feng Huang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Medicine, Research & Experimental

lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis

Yanni Ge et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Multidisciplinary Sciences

RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus

Rodney P. Kincaid et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms

Teresa M. Seccia et al.

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Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Andrew M. Kidger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

MiR-107 induces TNF-α secretion in endothelial cells causing tubular cell injury in patients with septic acute kidney injury

Shanshan Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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The extended human PTPome: a growing tyrosine phosphatase family

Andres Alonso et al.

FEBS JOURNAL (2016)

Article Medicine, Research & Experimental

Aberrantly methylated DNA regions lead to low activation of CD4+ T-cells in IgA nephropathy

Fabio Sallustio et al.

CLINICAL SCIENCE (2016)

Article Pharmacology & Pharmacy

Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update

Niloy Bhattacharjee et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Article Toxicology

Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38

Penjai Thongnuanjan et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2016)

Review Cell Biology

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

Andrew M. Kidger et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Review Toxicology

Compromised MAPK signaling in human diseases: an update

Eun Kyung Kim et al.

ARCHIVES OF TOXICOLOGY (2015)

Review Physiology

TRANSIENT RECEPTOR POTENTIAL CHANNELS IN THE VASCULATURE

Scott Earley et al.

PHYSIOLOGICAL REVIEWS (2015)

Article Multidisciplinary Sciences

The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck

Ju-Pi Li et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer

Fang-Ming Chen et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2012)

Review Oncology

Mesangial cell biology

Hanna E. Abboud

EXPERIMENTAL CELL RESEARCH (2012)

Review Biochemistry & Molecular Biology

DUSPs, to MAP kinases and beyond

Ching-Yu Huang et al.

CELL AND BIOSCIENCE (2012)

Article Cell Biology

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

Anna Kucharska et al.

CELLULAR SIGNALLING (2009)

Review Biochemistry & Molecular Biology

Multisite protein phosphorylation - from molecular mechanisms to kinetic models

Carlos Salazar et al.

FEBS JOURNAL (2009)

Article Chemistry, Multidisciplinary

Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II.: Role of ROCK and MAPK pathways

Raquel Rodrigues-Diez et al.

PHARMACEUTICAL RESEARCH (2008)

Review Biochemistry & Molecular Biology

Regulation of MAP kinases by MAP kinase phosphatases

Kunio Kondoh et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Review Biochemistry & Molecular Biology

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases

D. M. Owens et al.

ONCOGENE (2007)

Article Urology & Nephrology

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis

Frank Y. Ma et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

Article Urology & Nephrology

Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy

N Sakai et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2005)