期刊
BIOSENSORS-BASEL
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/bios12020109
关键词
drug delivery; mesoporous silica nanoparticles; nanomaterial; cancer; immunotherapy
资金
- National Natural Science Foundation of China [81872368, 81641051]
- Shenzhen Science and Technology Innovation Commission Key Projects of Fundamental Research and Program for Building Shenzhen City [JCYJ20180508152130899, ZDSYS20140509172959975, GJHZ20140416153844269, GuoKeFaJi[2018]38, JCYJ20140418112611757, JCYJ20130402145002438]
- Shenzhen Development and Reform Commission Subject Construction Project [[2017]1434]
- Science and Technology Innovation Commission of Shenzhen [RCBS20200714114910141, JCYJ20210324132816039]
- Start-up Grant at Harbin Institute of Technology (Shenzhen) [HA45001108, HA11409049]
- Shenzhen State Key Laboratories [JCYJ20180508152130899, ZDSYS20140509172959975, GJHZ20140416153844269, GuoKeFaJi[2018]38, JCYJ20140418112611757, JCYJ20130402145002438]
Immunotherapy is a promising treatment modality for cancer, using the body's immune response to fight against cancer. Mesoporous silica, as a nanomaterial, can facilitate the advancement of immunotherapy with its high porosity and biocompatibility.
Immunotherapy is a promising modality of treatment for cancer. Immunotherapy is comprised of systemic and local treatments that induce an immune response, allowing the body to fight back against cancer. Systemic treatments such as cancer vaccines harness antigen presenting cells (APCs) to activate T cells with tumor-associated antigens. Small molecule inhibitors can be employed to inhibit immune checkpoints, disrupting tumor immunosuppression and immune evasion. Despite the current efficacy of immunotherapy, improvements to delivery can be made. Nanomaterials such as mesoporous silica can facilitate the advancement of immunotherapy. Mesoporous silica has high porosity, decent biocompatibility, and simple surface functionalization. Mesoporous silica can be utilized as a versatile carrier of various immunotherapeutic agents. This review gives an introduction on mesoporous silica as a nanomaterial, briefly covering synthesis and biocompatibility, and then an overview of the recent progress made in the application of mesoporous silica tocancer immunotherapy.
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