期刊
ENDOCRINOLOGY AND METABOLISM
卷 36, 期 5, 页码 1055-1068出版社
KOREAN ENDOCRINE SOC
DOI: 10.3803/EnM.2021.1104
关键词
Hormones; Musclin protein, human (OSTN); Metabolic syndrome; Insulin resistance; Muscle, skeletal; Body composition
资金
- Colciencias-Coldeportes [626-2014, 111562638757]
- Colciencias (Beca de Doctorados Nacionales) [7272015]
- Convenio Interinstitucional IPS-Universitaria-Facultad de Medicina [13041]
- CODI [2565]
- Fundacion para la Promocion de la Investigacion y la Tecnologia (Banco de la Republica) [4.339]
The study showed that musclin in humans is positively correlated with insulin, insulin resistance, and certain body composition profiles, but not related to cardiorespiratory capacity.
Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring car-nosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometiy. Results: The control (n=29) and MS (n=61) groups were comparable in age (51.5 +/- 6.5 years old vs. 50.7 +/- 6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%+/- 7.4% vs. 57.3%+/- 6.8%), and peak oxygen consumption (VO2peak) (31.0 +/- 5.8 mL O-2./kg.min vs. 29.2 +/- 6.3 mL O-2/kg.min). Individuals with MS had higher body mass index (BM) (30.6 +/- 4.0 kg/m(2) vs. 27.4 +/- 3.6 kg/m(2)), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P<0.05). Musclin showed a significant relationship with HOMA-IR (beta=0.23; 95% CI, 0.12 to 0.33; P<0.01), but not with VO2peak, in multiple linear regression models adjusted for age, sex, fat mass, lean mass, and physical activity. Musclin was significantly associated with insulin, glycemia, visceral fat, and regional muscle mass, but not with BMI, VCO2peak, maximum heart rate, maximum time of work, or carnosine. Conclusion: In humans, musclin positively correlates with insulinemia, IR, and a body composition profile with high visceral adiposity and lean mass, but low body fat percentage. Musclin is not related to BMI or cardiorespiratory capacity.
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