4.7 Article

Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort

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TOXICS
卷 10, 期 1, 页码 -

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MDPI
DOI: 10.3390/toxics10010026

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persistent organic pollutants; dioxin-like activity; aryl hydrocarbon receptor; Greenlandic Inuit; pregnant women; fetal growth indices

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This study aims to measure the combined serum dioxin-like activity of lipophilic persistent organic pollutants (lipPOPs) in Greenlandic Inuit pregnant women and investigate the associations with fetal growth indices. The findings indicate significant dioxin-like activity in the serum samples, which is positively correlated with marine food intake and negatively correlated with body mass index and parity. Furthermore, higher dioxin-like activity is observed in women giving birth to infants with low birth weight and length, as well as in previous smokers.
Exposure to lipophilic persistent organic pollutants (lipPOPs) elicits a number of species- and tissue-specific toxic responses, many of which involve the aryl hydrocarbon receptor (AhR). This study aims to measure the combined serum dioxin-like activity of lipPOPs in Greenlandic Inuit pregnant women and the associations with fetal growth indices. The combined dioxin-like activity of serum lipPOPs extracts was determined using the AhR reporter gene bioassay and expressed as pico-gram (pg) TCDD equivalent (TEQ) per gram serum lipid [AhR-TEQ (pg/g lipid)]. Significant AhR-TEQ was found in >87% of serum samples with the median level of 86.2 pg TEQ/g lipid. The AhR-TEQ level positively correlated with the marine food intake biomarker n-3/n-6 polyunsaturated fatty acids ratio, while negatively correlated with body mass index and parity. Women giving birth to infants with low birth weight (<2500 g) and length (<50 cm) had higher AhR-TEQ level compared to those with normal weight and length infants. For previous smokers, we found significant inverse associations between maternal AhR-TEQ level and fetal growth indices. In conclusion, exposure of Greenlandic Inuit pregnant women to dioxin-like compounds through traditional marine food can adversely influence the fetal growth via induced AhR activity. Smoking might have modifying effects.

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