4.6 Review

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

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A review on chemical and physical modifications of phytosterols and their influence on bioavailability and safety

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Summary: Chemical and physical modifications of phytosterols can effectively increase their absorption and bioavailability. Safety is a concern, with phytosterol esters generally considered safe, but potential toxicity from phytosterol oxides and nanocarriers needing further study.

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Summary: Breast cancer, a highly heterogeneous disease, is a leading cause of death among women globally. Chemotherapeutic resistance poses a major challenge in successful treatment. Nanotechnology research has revolutionized over the years, with the development of smart polymers, targeting ligands, and other advanced technologies. Novel nano-pharmaceutical design is focusing on making chemotherapy curative and long-lasting.

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Nutraceutical nanodelivery; an insight into the bioaccessibility/bioavailability of different bioactive compounds loaded within nanocarriers

Cristian Dima et al.

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CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2021)

Article Chemistry, Applied

Acetylated debranched starch micelles as a promising nanocarrier for curcumin

Qing Liu et al.

Summary: Natural amphiphilic polymer micelles modified from debranched starch with acetic anhydride exhibit excellent loading capacity and sustained release properties. The micelles are characterized by their small size and high stability, making them suitable for efficient delivery of hydrophobic functional ingredients.

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Review Biotechnology & Applied Microbiology

Advances in encapsulin nanocompartment biology and engineering

Jesse A. Jones et al.

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BIOTECHNOLOGY AND BIOENGINEERING (2021)

Review Food Science & Technology

Starch-based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Mengting Yu et al.

Summary: Starch-based nanoparticles have garnered attention for their small size, biocompatibility, and potential applications in various fields. They are enzymatically hydrolyzed into glucose in vivo and can be utilized as enzyme-responsive carriers. These nanoparticles are non-toxic, responsive to various stimuli, and can interact with other components through electrostatic and hydrogen bonding interactions, offering a wide range of applications in enhancing mechanical properties, stabilizing emulsions, and controlling release of active ingredients and drugs.

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Colon-targeted drug delivery of polysaccharide-based nanocarriers for synergistic treatment of inflammatory bowel disease: A review

Mingxiao Cui et al.

Summary: Polysaccharide-based nanocarriers can help reduce the side effects of drugs used for treating inflammatory bowel disease (IBD) by targeting the colon and enhancing their bioavailability. Polysaccharides also play a role in alleviating IBD through their anti-inflammatory and intestinal microecological regulatory effects.

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Article Materials Science, Biomaterials

Biodegradable nanocarriers based on chitosan-modified mesoporous silica nanoparticles for delivery of methotrexate for application in breast cancer treatment

Zahra Shakeran et al.

Summary: Nanocarriers, specifically mesoporous silica nanoparticles (MSNs), have shown great potential in delivering hydrophobic drugs like methotrexate (MTX) to tumor spaces. Surface-modified MSNs were loaded with MTX and studied for their drug release, cellular uptake and cytotoxic effects on breast cancer cells, showing promising results at a low dose.

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Review Chemistry, Applied

The development of natural and designed protein nanocages for encapsulation and delivery of active compounds

Hai Chen et al.

Summary: Protein nanocages are three-dimensional shell-like containers assembled from multiple subunits in high symmetry, with a homogeneous chamber segregated by protein walls. They are increasingly being explored as nano-vehicles for encapsulating active compounds or drugs to enhance their properties and bioavailability. Various strategies for molecular encapsulation within protein nanocages have been summarized, with a focus on the encapsulation and delivery of food bioactive compounds. Despite challenges such as low yields and high costs, further research is necessary for the development of protein nanocages as novel nano-vehicles for food active compounds.

FOOD HYDROCOLLOIDS (2021)

Article Pharmacology & Pharmacy

Stimuli-responsive nanoliposomes as prospective nanocarriers for targeted drug delivery

Muhammad Bilal et al.

Summary: This review discusses the advantages and mechanisms of nanoliposomes for targeted drug delivery, as well as the stimulation-responsive targeting approaches for efficient cancer therapy. Various targeting strategies and challenges associated with these systems are also detailed in this review.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

Article Food Science & Technology

Sodium caseinate-coated and β-cyclodextrin/vitamin E inclusion complex-loaded nanoliposomes: A novel stabilized nanocarrier

Jamile Souri et al.

Summary: The study successfully loaded beta-cyclodextrin/vitamin E inclusion complex in liposomes and coated them with sodium caseinate, resulting in a nanocarrier with improved thermal stability and sustained release profile.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

Article Chemistry, Applied

Enhancing the resistance of anthocyanins to environmental stress by constructing ovalbumin-propylene glycol alginate nanocarriers with novel configurations

Xinyue Zhang et al.

Summary: The study demonstrates that OVA-propylene glycol alginate nanocomplexes (Type II) with novel configurations can provide guidance for developing ACNs and other bioactive substance delivery systems as food functional ingredients.

FOOD HYDROCOLLOIDS (2021)

Review Chemistry, Multidisciplinary

Nanoemulsions for health, food, and cosmetics: a review

Tolulope Joshua Ashaolu

Summary: Nanoemulsions are becoming increasingly important in healthcare and cosmetics sectors due to the unique properties of nanosized droplets, such as high surface area. The review focuses on nanotechnology and nanoemulsions, with discussions on emulsifiers, nanoemulsifiers, and various applications in drugs and vaccines delivery, cancer therapy, inflammation treatment, cosmetics, perfumes, polymers, and food. Safety and properties of nanoemulsion, including stability, emulsification, solubility, molecular number and arrangements, ionic strength, pH, and temperature, are also discussed.

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Design of liposomes as drug delivery system for therapeutic applications

Diana Guimaraes et al.

Summary: Liposomes are effective drug delivery systems that improve therapeutic efficacy, being nontoxic and biodegradable. Key aspects such as design, production techniques, drug loading, and characterization for in vitro and in vivo performance are essential for successful liposomal formulations. Other topics explored include functionalization, targeting strategies, stability, limitations, and current market applications of liposomes in various therapeutic fields.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

Nidhi Raval et al.

Summary: Polymeric micelles have been a popular research topic in the past decade, particularly in their ability to deliver drugs and diagnostic agents effectively. They offer advantages such as biocompatibility, high loading efficiency, and stability in biological fluids. This technology shows promising potential in cancer treatment but also presents challenges in clinical application.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Food Science & Technology

Recent updates on the chemistry, bioactivities, mode of action, and industrial applications of plant essential oils

Zhi-Jing Ni et al.

Summary: Essential oils, natural active compounds, have been widely used in food and pharmaceutical industries for their flavor and fragrance. Recent studies have shown significant biological activities and health benefits of essential oils, leading to their potential as safe alternative therapeutics in various industries.

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Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer

Hannah J. Vaughan et al.

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MOLECULAR THERAPY-ONCOLYTICS (2021)

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Liposome surface modification by phospholipid chemical reactions

Pedro Henrique Correia de Lima et al.

Summary: Actively target liposomes are a novel class of nanoparticles that have surface modifications with appropriate ligands to actively bind target molecules, with various ways of functionalization. This review focuses on modifying liposomes through glycerophospholipid covalent chemical reactions, summarizing the main strategies used in phospholipid modification for chemists and researchers from other disciplines. Understanding these methodologies is crucial for planning new studies and manipulating the properties of these nanostructures.

CHEMISTRY AND PHYSICS OF LIPIDS (2021)

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Solid lipid nanoparticles for hydrophilic drugs

Yashika Mirchandani et al.

Summary: Hydrophilic drugs are effective therapeutic agents, but the delivery of these drugs presents challenges. Various colloidal drug delivery systems have been developed to enhance drug entrapment and bioavailability, but issues like drug leakage and burst release remain. Solid lipid nanoparticles (SLNs) have been proposed as an alternative to overcome these issues, and research is focusing on different approaches for the delivery of hydrophilic drugs using SLNs.

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Nanomaterials for cancer therapy: current progress and perspectives

Zhe Cheng et al.

Summary: Nanomaterials play an important role in cancer therapy by targeting cancer cells, tumor microenvironment, and the immune system. However, despite an increasing number of studies, the approval of nano-drugs has not significantly increased, requiring further research to improve clinical translation efficiency.

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Formulation and characterization of β-caryophellene-loaded lipid nanocarriers with different carrier lipids for food processing applications

Min Hyeock Lee et al.

Summary: In this study, beta-caryophellene (BCP) was encapsulated in lipid nanocarriers using different carrier lipids, and the effects of various food processing treatments on physical stability were investigated. The results showed that lipid nanocarriers with MCT oil exhibited high dispersion stability, especially after freeze-thaw treatments.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Co-encapsulation of resveratrol and epigallocatechin gallate in low methoxyl pectin-coated liposomes with great stability in orange juice

Simin Feng et al.

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Development of amphotericin B-loaded propionate Sterculia striata polysaccharide nanocarrier

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Dendrimers in the context of nanomedicine

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Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation

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Eliana B. Souto et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

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Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

Mohamed Haider et al.

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Nano-lipid carriers stabilized by hydrophobically modified starch or sucrose stearate for the delivery of lutein as a nutraceutical beverage model

Ali Sedaghat Doost et al.

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A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms

Koichi Yoshimura et al.

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Purification and characterizations of a nanocage ferritin GF1 from oyster (Crassostrea gigas)

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Matthieu Germain et al.

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A systematic review on nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers

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Nanoemulsions: Factory for Food, Pharmaceutical and Cosmetics

Nor Azrini Nadiha Azmi et al.

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Physical PEGylation Enhances The Cytotoxicity Of 5-Fluorouracil-Loaded PLGA And PCL Nanoparticles

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Thermoresponsive polymer nanocarriers for biomedical applications

Alexandre Bordat et al.

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Use of Lipid Nanocarriers to Improve Oral Delivery of Vitamins

Ching-Yun Hsu et al.

NUTRIENTS (2019)

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Nanocarrier-based systems for targeted and site specific therapeutic delivery

Joydeb Majumder et al.

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Therapeutic efficacy of nanoparticles and routes of administration

Dhrisya Chenthamara et al.

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Lipid-chitosan hybrid nanoparticles for controlled delivery of cisplatin

Muhammad Muzamil Khan et al.

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Improving emulsion formation, stability and performance using mixed emulsifiers: A review

David Julian McClements et al.

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Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

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Protein-Based Delivery Systems for the Nanoencapsulation of Food Ingredients

Milad Fathi et al.

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Stability, biocompatibility and antioxidant activity of PEG-modified liposomes containing resveratrol

Carla Caddeo et al.

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Polymer-Stabilized Micelles Reduce the Drug Rapid Clearance In Vivo

Shan-Ni Wen et al.

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Lipid nano scale cargos for the protection and delivery of food bioactive ingredients and nutraceuticals

Sahar Akhavan et al.

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Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems

Twana Mohammed M. Ways et al.

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Epidermal growth factor receptor based active targeting: a paradigm shift towards advance tumor therapy

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Drug nanocrystallisation within liposomes

Tang Li et al.

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Protein Corona Mediated Stealth Properties of Biocompatible Carbohydrate-based Nanocarriers

Johanna Simon et al.

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Precise nanomedicine for intelligent therapy of cancer

Huabing Chen et al.

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Soy Soluble Polysaccharide as a Nanocarrier for Curcumin

Fei-Ping Chen et al.

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Silica Nanoparticle-Induced Blockage of Autophagy Leads to Autophagic Cell Death in HepG2 Cells

Yongbo Yu et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2017)

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Biomimetics in drug delivery systems: A critical review

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Topical and cutaneous delivery using nanosystems

M. S. Roberts et al.

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Review Chemistry, Multidisciplinary

Nanoemulsion: Concepts, development and applications in drug delivery

Yuvraj Singh et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Liposome-based drug co-delivery systems in cancer cells

Sepideh Zununi Vahed et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Polymer vesicles: Mechanism, preparation, application, and responsive behavior

Yunqing Zhu et al.

PROGRESS IN POLYMER SCIENCE (2017)

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Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

Supandeep Singh Hallan et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

Review Pharmacology & Pharmacy

Therapeutic Potential of Drug Delivery by Means of Lipid Nanoparticles: Reality or Illusion?

Melike Uner et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Review Chemistry, Multidisciplinary

Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs

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PHARMACEUTICAL RESEARCH (2016)

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Long-term stability of food-grade nanoemulsions from high methoxyl pectin containing essential oils

Maria Ines Guerra-Rosas et al.

FOOD HYDROCOLLOIDS (2016)

Review Biotechnology & Applied Microbiology

Essential oil nanoemulsions as antimicrobial agents in food

Francesco Donsi et al.

JOURNAL OF BIOTECHNOLOGY (2016)

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Drug delivery and drug targeting with parenteral lipid nanoemulsions - A review

Karl Hoermann et al.

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Nanoemulsions: formation, properties and applications

Ankur Gupta et al.

SOFT MATTER (2016)

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Lipid polymer hybrid as emerging tool in nanocarriers for oral drug delivery

Supandeep Singh Hallan et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2016)

Review Chemistry, Multidisciplinary

Hyperbranched polymer vesicles: from self-assembly, characterization, mechanisms, and properties to applications

Wenfeng Jiang et al.

CHEMICAL SOCIETY REVIEWS (2015)

Article Pharmacology & Pharmacy

Mucoadhesive Chitosan Derivatives as Novel Drug Carriers

Mohammad Ariful Islam et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Article Food Science & Technology

Effect of chitosan nanoparticles loaded with cinnamon essential oil on the quality of chilled pork

Jing Hu et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2015)

Article Multidisciplinary Sciences

Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

Tuo Wei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Jafar Ezzati Nazhad Dolatabadi et al.

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Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry

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ACS NANO (2014)

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Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers

Yuanpei Li et al.

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Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery

Koen Raemdonck et al.

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Drug targeting using solid lipid nanoparticles

Elham Rostami et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2014)

Article Agriculture, Multidisciplinary

Fabrication of Epigallocatechin-3-gallate Nanocarrier Based on Glycosylated Casein: Stability and Interaction Mechanism

Jin Xue et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

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Enhanced Antibacterial Effects of Clove Essential Oil by Nanoemulsion

Md Khalid Anwer et al.

JOURNAL OF OLEO SCIENCE (2014)

Review Pharmacology & Pharmacy

Liposomal drug delivery systems: From concept to clinical applications

Theresa M. Allen et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Nanocarriers for intravenous injection-The long hard road to the market

Matthias Wacker

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Polymeric nanoparticles for drug delivery to the central nervous system

Toral Patel et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Article Chemistry, Medicinal

Anti-glioma Effect and Safety of Docetaxel-loaded Nanoemulsion

Huil Gaoe et al.

ARCHIVES OF PHARMACAL RESEARCH (2012)

Article Pharmacology & Pharmacy

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

Anu Puri et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2012)

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EGF receptor-targeted nanocarriers for enhanced cancer treatment

Alyssa M. Master et al.

NANOMEDICINE (2012)

Review Chemistry, Multidisciplinary

Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine

Wafa' T. Al-Jamal et al.

ACCOUNTS OF CHEMICAL RESEARCH (2011)

Review Pharmacology & Pharmacy

Nanoparticles and microparticles for skin drug delivery

Tar W. Prow et al.

ADVANCED DRUG DELIVERY REVIEWS (2011)

Article Toxicology

Titanium dioxide nanoparticles impair lung mitochondrial function

Veronica Freyre-Fonseca et al.

TOXICOLOGY LETTERS (2011)

Article Biochemistry & Molecular Biology

Receptor-targeted nanocarriers for therapeutic delivery to cancer

Bo Yu et al.

MOLECULAR MEMBRANE BIOLOGY (2010)

Review Chemistry, Multidisciplinary

Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release

Chris Oerlemans et al.

PHARMACEUTICAL RESEARCH (2010)

Article Peripheral Vascular Disease

Nanoparticle-mediated targeting of phosphatidylinositol-3-kinase signaling inhibits angiogenesis

Rania Harfouche et al.

ANGIOGENESIS (2009)

Article Medicine, Research & Experimental

Coadministration of Paclitaxel and Curcumin in Nanoemulsion Formulations To Overcome Multidrug Resistance in Tumor Cells

Srinivas Ganta et al.

MOLECULAR PHARMACEUTICS (2009)

Article Chemistry, Multidisciplinary

Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform

Liangfang Zhang et al.

ACS NANO (2008)

Review Pharmacology & Pharmacy

Nanostructured lipid carriers (NLC) in cosmetic dermal products

R. H. Mueller et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

Review Pharmacology & Pharmacy

Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles

Ho Lun Wong et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

Review Chemistry, Multidisciplinary

Micellar nanocarriers: Pharmaceutical perspectives

V. P. Torchilin

PHARMACEUTICAL RESEARCH (2007)

Article Chemistry, Applied

Stabilization of oils by microencapsulation with heated protein-glucose syrup mixtures

Jenny Kartika Rusli et al.

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (2006)

Review Biotechnology & Applied Microbiology

Designing dendrimers for biological applications

CC Lee et al.

NATURE BIOTECHNOLOGY (2005)

Review Pharmacology & Pharmacy

Tocol emulsions for drug solubilization and parenteral delivery

PP Constantinides et al.

ADVANCED DRUG DELIVERY REVIEWS (2004)

Review Chemistry, Medicinal

Amphiphilic block copolymers for drug delivery

ML Adams et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2003)

Review Pharmacology & Pharmacy

Solid lipid nanoparticles (SLN) for controlled drug delivery -: a review of the state of the art

RH Müller et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2000)