期刊
FRONTIERS IN NUTRITION
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2021.781333
关键词
vitamins; helicobacter pylori; meta-analysis; systematic review; relationship
资金
- Soft Science Key Project of the Science and Technology Department of Zhejiang Province [2019C25009, 2022C25040]
- Key Project of Social Science Planning in Hangzhou City [hzjz20180110]
- Soft Science Key Project of Hangzhou Municipal Science Committee [20160834M03]
- Ningbo Clinical Medicine Research Center Project [2019A21003]
- Zhejiang Provincial Natural Science Foundation [LQ21H160013]
- Zhejiang Provincial Medical and Health Science and Technology Project [2022493920]
- Chiatai Qingchunbao Pharmaceutical Co. Ltd.
H. pylori infection decreases serum levels of various vitamins, eradication of H. pylori can reverse its adverse effects, and antioxidant vitamin supplementation may improve the eradication rate of H. pylori.
Background: Over recent decades, epidemiological studies have shown relationships between vitamins and Helicobacter pylori (H. pylori) infection and eradication, but the results are controversial.Methods: A comprehensive meta-analysis and systematic review were conducted to clarify the relationships between common types of vitamins and H. pylori. We applied meta-regression, subgroup analysis and sensitivity analysis to obtain available evidence. Articles published from January 1991 to June 2021 in PubMed, EMBASE, and the Cochrane Library were searched.Results: In total, we identified 48 studies. The results indicate that H. pylori -positive patients had lower serum vitamin B-12 [standardized mean difference (SMD) = -0.30; 95% confidence interval (CI): -0.53 - -0.08], folate (SMD = -0.69; 95% CI: -1.34 - -0.04), vitamin C (SMD = -0.37; 95%CI: -0.57 - -0.18) and vitamin D (SMD = -0.34; 95% CI: -0.49 - -0.18) levels than H. pylori-negative patients. Patients in which H. pylori had been successfully eradicated had higher serum vitamin D levels (SMD = 1.37; 95% CI: 0.37-2.38) than in patients in which eradication had been unsuccessful. The serum vitamin B-12 levels of H. pylori-positive patients improved after successful H. pylori eradication therapy (SMD = 1.85; 95% CI: 0.81-2.90), and antioxidant vitamin supplementation to an H. pylori eradication regimen improved the eradication rate (risk ratio = 1.22; 95% CI: 1.02-1.44 for per-protocol analysis; risk ratio = 1.25; 95% CI: 1.06-1.47 for intention-to-treat analysis).Conclusions: H. pylori infections decrease the serum levels of several types of vitamins, eradication of H. pylori could rescue its adverse effects, and antioxidant vitamin supplementation may improve the H. pylori eradication rate.
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