期刊
KIDNEY INTERNATIONAL REPORTS
卷 7, 期 3, 页码 455-464出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ekir.2021.12.025
关键词
hypoxia-inducible factor prolyl hydroxylase inhibitor; peritoneal dialysis; renal anemia; roxadustat
资金
- Scientific Research Project of Capital Health Development [2020-2-4079]
- CAMS Innovation Fund for Medical Sciences [2019-I2M-5-046]
- Youth Clinical Research Project Of Peking University First Hospital [2017CR03, 2019CR25]
This study aimed to compare the efficacy of a lower starting dose of roxadustat with the standard dose among PD patients. The results showed no difference in achieving the Hb target between the low-dose and standard-dose groups. Both groups showed significant improvement in Hb levels.
Introduction: We aimed to investigate whether a lower starting dose of roxadustat (similar to 1-1.4 mg/kg) converted from erythropoiesis-stimulating agent (ESA) could achieve a comparable hemoglobin (Hb) target (>= 100 and <= 120 g/l) compared with the standard weight-based dose (similar to 1.5-2 mg/kg) at week 12 through a peritoneal dialysis (PD) cohort. Methods: A 12-week multicenter randomized, parallel-controlled, open-label, pilot clinical trial enrolled adult patients who had undergone PD treatment for >3 months with renal anemia. Participants were randomized in blocks of 4 in a 1:1 ratio to either the standard-dose group (n = 50) or the low-dose group (n = 50). The primary end point was the proportion of patients achieving the Hb target at week 12. Results: Baseline demographic and clinical characteristics of the 2 groups were comparable. There was no difference in the proportion of patients who met the Hb target at week 12, that is, 26 patients (52%) versus 31 patients (62%) in the low-dose group and standard-dose group, respectively (P= 0.31). The Hb levels significantly increased in both groups from baseline to week 12; the median change of Hb levels was 5.0 (0.0-14.3) g/l (P < 0.001) for the standard-dose group and 6.0 (-3.3 to 16.3) g/l for the low-dose group (P = 0.005) (P = 0.581 for between groups). Conclusion: This study suggests that a lower starting dose of roxadustat effectively achieves the Hb target as standard-dose does among patients on PD.
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