相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Therapeutic genome editing in cardiovascular diseases
Masataka Nishiga et al.
ADVANCED DRUG DELIVERY REVIEWS (2021)
A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression
Rachael E. Workman et al.
CELL (2021)
A two-pronged approach to regulate the behaviors of ECs and SMCs by the dual targeting-nanoparticles
Xiaoyu Wang et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2021)
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice
Luke W. Koblan et al.
NATURE (2021)
Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization
Ilaria Gori et al.
ELIFE (2021)
Genomic Landscapes of Noncoding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells
Isidore Mushimiyimana et al.
MOLECULAR AND CELLULAR BIOLOGY (2021)
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Kiran Musunuru et al.
NATURE (2021)
Long noncoding RNAs: Potential therapeutic targets in cardiocerebrovascular diseases
Hao Zhang et al.
PHARMACOLOGY & THERAPEUTICS (2021)
Exosome-eluting stents for vascular healing after ischaemic injury
Shiqi Hu et al.
NATURE BIOMEDICAL ENGINEERING (2021)
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
Gregory A. Newby et al.
NATURE (2021)
Generation of genetically modified human induced pluripotent stem cell lines harboring haploin sufficient or dominant negative variants in the FBN1 gene
Juliana Borsoi et al.
STEM CELL RESEARCH (2021)
Liposomal delivery of CRISPR/Cas9
Shuai Zhen et al.
CANCER GENE THERAPY (2020)
In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia
Huan Zhao et al.
CIRCULATION (2020)
The promise and challenge of therapeutic genome editing
Jennifer A. Doudna
NATURE (2020)
Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors
Jordan L. Doman et al.
NATURE BIOTECHNOLOGY (2020)
In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency Implications for SMAD3-Related Thoracic Aortic Aneurysm
Jian Gong et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)
Genome editing with the CRISPR-Cas system: an art, ethics and global regulatory perspective
Debin Zhang et al.
PLANT BIOTECHNOLOGY JOURNAL (2020)
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
Xiaohui Zhang et al.
NATURE BIOTECHNOLOGY (2020)
A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
Julian Grunewald et al.
NATURE BIOTECHNOLOGY (2020)
Homozygous familial hypercholesterolemia: what treatments are on the horizon?
Archna Bajaj et al.
CURRENT OPINION IN LIPIDOLOGY (2020)
Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters
Mengmeng Guo et al.
CIRCULATION RESEARCH (2020)
Definition of a Novel Plasmid-Based Gene Transfection Protocol of Mammalian Skeletal Muscles by Means of In Vivo Electroporation
Enrico P. Spugnini et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
The genome editing revolution: review
Ahmad M. Khalil
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2020)
Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases
Chih-Fan Yeh et al.
JOURNAL OF BIOMEDICAL SCIENCE (2020)
Losses of human disease-associated genes in placental mammals
Virag Sharma et al.
NAR GENOMICS AND BIOINFORMATICS (2020)
CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool
Carolyn Brokowski et al.
JOURNAL OF MOLECULAR BIOLOGY (2019)
Ethics of Human Genome Editing
Barry S. Coller
ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)
Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease
Brian A. Ference et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Erwei Zuo et al.
SCIENCE (2019)
The ethics of genome editing in non-human animals: a systematic review of reasons reported in the academic literature
Nienke de Graeff et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)
CRISPR/Cas9 Delivery Mediated with Hydroxyl-Rich Nanosystems for Gene Editing in Aorta
Xiaoping Zhang et al.
ADVANCED SCIENCE (2019)
Triple-Targeting Delivery of CRISPR/Cas9 to Reduce the Risk of Cardiovascular Diseases
Lingmin Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Long Noncoding RNAs of the Arterial Wall as Therapeutic Agents and Targets in Atherosclerosis
Lesca M. Holdt et al.
THROMBOSIS AND HAEMOSTASIS (2019)
Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation
Wen Tian et al.
CIRCULATION (2019)
The Long Non-Coding RNA Landscape of Atherosclerotic Plaques
Weronika Kraczkowska et al.
MOLECULAR DIAGNOSIS & THERAPY (2019)
Search-and-replace genome editing without double-strand breaks or donor DNA
Andrew V. Anzalone et al.
NATURE (2019)
Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism
Gissette Reyes-Soffer et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)
Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease
Wen Dai et al.
LIPIDS IN HEALTH AND DISEASE (2019)
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (vol 140, e596, 2019)
Donna K. Arnett et al.
CIRCULATION (2019)
Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke
Jemma C. Hopewell et al.
EUROPEAN HEART JOURNAL (2018)
PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy
Zufeng Ding et al.
CARDIOVASCULAR RESEARCH (2018)
Ethical issues in genetic modification and why application matters
Megan Munsie et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)
Delivering CRISPR: a review of the challenges and approaches
Christopher A. Lino et al.
DRUG DELIVERY (2018)
Applications of CRISPR/Cas System to Bacterial Metabolic Engineering
Suhyung Cho et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
Luke W. Koblan et al.
NATURE BIOTECHNOLOGY (2018)
Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide
Hong-Xia Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies
Fang Yuan et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)
Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs
Yao Lin et al.
ADVANCED SCIENCE (2018)
A Novel Cause of Familial Hypercholesterolemia: PCSK9 Gene Duplication
Martine Paquette et al.
CANADIAN JOURNAL OF CARDIOLOGY (2018)
Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries
Gonca Suna et al.
CIRCULATION (2018)
Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection
Marjolijn Renard et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)
Correction of the Marfan Syndrome Pathogenic FBN1 Mutation by Base Editing in Human Cells and Heterozygous Embryos
Yanting Zeng et al.
MOLECULAR THERAPY (2018)
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
Jason M. Gehrke et al.
NATURE BIOTECHNOLOGY (2018)
Fluorinated Acid-Labile Branched Hydroxyl-Rich Nanosystems for Flexible and Robust Delivery of Plasmids
Yu Qi et al.
SMALL (2018)
Inflammation, Immunity, and Infection in Atherothrombosis JACC Review Topic of the Week
Peter Libby et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)
CRISPR/Cas9 gene-editing: Research technologies, clinical applications and ethical considerations
Fani Memi et al.
SEMINARS IN PERINATOLOGY (2018)
Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPARγ-LXRα-ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque
Huan Wang et al.
THERANOSTICS (2018)
Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis
Bradley K. Wacker et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)
Nonintegrating Gene Therapy Vectors
Takis Athanasopoulos et al.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2017)
Trends and Patterns of Geographic Variation in Cardiovascular Mortality Among US Counties, 1980-2014
Gregory A. Roth et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
Nathan O. Stitziel et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)
Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial
Robert P. Giugliano et al.
LANCET (2017)
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
Gaelen T. Hess et al.
MOLECULAR CELL (2017)
Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage
Nicole M. Gaudelli et al.
NATURE (2017)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin et al.
NATURE BIOTECHNOLOGY (2017)
Genetics: ANGPTL3 deficiency protects from CAD
Irene Fernández-Ruiz
Nature Reviews Cardiology (2017)
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
F. E. Dewey et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
P. M. Ridker et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Targeted Delivery of CRISPR/Cas9-Mediated Cancer Gene Therapy via Liposome-Templated Hydrogel Nanoparticles
Zeming Chen et al.
ADVANCED FUNCTIONAL MATERIALS (2017)
Transforming Growth Factor β1-and Bone Morphogenetic Protein 2/PPARγ-regulated MicroRNAs in Pulmonary Arterial Hypertension
Laurent Calvier et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)
Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia
Peter Tontonoz et al.
CIRCULATION (2017)
Dysfunctional HDL and atherosclerotic cardiovascular disease
Robert S. Rosenson et al.
NATURE REVIEWS CARDIOLOGY (2016)
PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases
Rui-Quan Li et al.
ADVANCED MATERIALS (2016)
A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension
Lai-Ming Yung et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)
Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II-Induced Abdominal Aortic Aneurysms in C57BL/6 MiceBrief Report
Hong Lu et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo-Brief Report
Xiao Wang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
Activation of Peroxisome Proliferator-Activated Receptor- as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis
Jarkko Hytonen et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification
Claudia Goettsch et al.
ATHEROSCLEROSIS (2016)
Enhanced biocompatibility of CD47-functionalized vascular stents
Joshua B. Slee et al.
BIOMATERIALS (2016)
Pathogenic FBN1 variants in familial thoracic aortic aneurysms and dissections
E. S. Regalado et al.
CLINICAL GENETICS (2016)
Advances in stent-mediated gene delivery
Muhammad Yasir Adeel et al.
EXPERT OPINION ON DRUG DELIVERY (2016)
TALEN gene editing takes aim on HIV
Ronald Benjamin et al.
HUMAN GENETICS (2016)
PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis
Anne Langsted et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Alexis C. Komor et al.
NATURE (2016)
Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis
Tamer Sallam et al.
NATURE (2016)
Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity
Duy P. Nguyen et al.
NATURE COMMUNICATIONS (2016)
Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts
Kazuhiro Umeyama et al.
SCIENTIFIC REPORTS (2016)
Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases
Johnny H. Hu et al.
CELL CHEMICAL BIOLOGY (2016)
Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation
Melvin Y. Rincon et al.
CARDIOVASCULAR RESEARCH (2015)
Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII
Haibo Li et al.
CARDIOVASCULAR RESEARCH (2015)
Neoatherosclerosis: overview of histopathologic findings and implications for intravascular imaging assessment
Fumiyuki Otsuka et al.
EUROPEAN HEART JOURNAL (2015)
Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses
Dan Wang et al.
HUMAN GENE THERAPY (2015)
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran et al.
NATURE (2015)
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
Lu Long et al.
NATURE MEDICINE (2015)
Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
Jennifer G. Robinson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice
Gou Takahashi et al.
SCIENTIFIC REPORTS (2015)
Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E-/- mice without influencing systemic atherosclerosis
Markus Theurl et al.
CARDIOVASCULAR RESEARCH (2015)
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society
Marina Cuchel et al.
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY (2015)
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
Randall J. Platt et al.
CELL (2014)
The Genetics of Pulmonary Arterial Hypertension
Eric D. Austin et al.
CIRCULATION RESEARCH (2014)
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
Qiurong Ding et al.
CIRCULATION RESEARCH (2014)
General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination
Aline Baldo et al.
CURRENT GENE THERAPY (2014)
Loeys-Dietz syndrome: a primer for diagnosis and management
Gretchen MacCarrick et al.
GENETICS IN MEDICINE (2014)
CRISPR/Cas9 for genome editing: progress, implications and challenges
Feng Zhang et al.
HUMAN MOLECULAR GENETICS (2014)
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
Danilo Maddalo et al.
NATURE (2014)
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing
Dirk Heck et al.
NATURE BIOTECHNOLOGY (2014)
APOC3 mutations lower CVD risk
Tim Geach
Nature Reviews Cardiology (2014)
Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
Anders Berg Jorgensen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
Jacy Crosby et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
Chengzu Long et al.
SCIENCE (2014)
Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering
Takuro Horii et al.
SCIENTIFIC REPORTS (2014)
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society
Marina Cuchel et al.
EUROPEAN HEART JOURNAL (2014)
Correction of Nonsense BMPR2 and SMAD9 Mutations by Ataluren in Pulmonary Arterial Hypertension
Kylie M. Drake et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)
Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: Implications for gene therapy of restenosis
Scott P. Forbes et al.
ATHEROSCLEROSIS (2013)
Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9
Yuxuan Wu et al.
CELL STEM CELL (2013)
TAL effectors: function, structure, engineering and applications
Amanda Nga-Sze Mak et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)
The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations
Benjamin J. Dunmore et al.
HUMAN MOLECULAR GENETICS (2013)
FK506 activates BMPR2 rescues endothelial dysfunction, and reverses pulmonary hypertension
Edda Spiekerkoetter et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Generation of an HIV Resistant T-cell Line by Targeted Stacking of Restriction Factors
Richard A. Voit et al.
MOLECULAR THERAPY (2013)
INNOVATION TALENs: a widely applicable technology for targeted genome editing
J. Keith Joung et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA-targeting proteins
Erin L. Doyle et al.
TRENDS IN CELL BIOLOGY (2013)
Inflammation in Atherosclerosis
Peter Libby
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
Liver X Receptors, Atherosclerosis and Inflammation
Daryn R. Michael et al.
CURRENT ATHEROSCLEROSIS REPORTS (2012)
Targeted gene delivery of BMPR2 attenuates pulmonary hypertension
A. M. Reynolds et al.
EUROPEAN RESPIRATORY JOURNAL (2012)
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
Mark E. Lindsay et al.
NATURE GENETICS (2012)
TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome
Catherine Boileau et al.
NATURE GENETICS (2012)
Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm
Alexander J. Doyle et al.
NATURE GENETICS (2012)
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
Cherie L. Ramirez et al.
NUCLEIC ACIDS RESEARCH (2012)
Chimeric TALE recombinases with programmable DNA sequence specificity
Andrew C. Mercer et al.
NUCLEIC ACIDS RESEARCH (2012)
Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
Sebastian Bultmann et al.
NUCLEIC ACIDS RESEARCH (2012)
Dysfunctional HDL: A novel important diagnostic and therapeutic target in cardiovascular disease?
Aneta Otocka-Kmiecik et al.
PROGRESS IN LIPID RESEARCH (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains
Le Cong et al.
NATURE COMMUNICATIONS (2012)
Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR-/- mice
G. Li et al.
GENE THERAPY (2011)
Genome Engineering With Zinc-Finger Nucleases
Dana Carroll
GENETICS (2011)
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller et al.
NATURE BIOTECHNOLOGY (2011)
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
Tomas Cermak et al.
NUCLEIC ACIDS RESEARCH (2011)
TAL Effectors: Customizable Proteins for DNA Targeting
Adam J. Bogdanove et al.
SCIENCE (2011)
Genetic dissection of axon regeneration via in vivo electroporation of adult mouse sensory neurons
Saijilafu et al.
NATURE COMMUNICATIONS (2011)
Regulation of Hepatic ApoC3 Expression by PGC-1β Mediates Hypolipidemic Effect of Nicotinic Acid
Carlos Hemandez et al.
CELL METABOLISM (2010)
Marfan syndrome. Part 1: pathophysiology and diagnosis
Victoria Canadas et al.
NATURE REVIEWS CARDIOLOGY (2010)
Macrophage Reverse Cholesterol Transport in Mice Expressing ApoA-I Milano
Eric T. Alexander et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity
Eva-Maria Haendel et al.
MOLECULAR THERAPY (2009)
Fat and beyond: The diverse biology of PPAR gamma
Peter Tontonoz et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2008)
Regulation of macrophage functions by PPAR-α, PPAR-γ, and LXRs in mice and men
Elena Rigamonti et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
Peroxisome proliferator-activated receptor-γ1 gene therapy attenuates atherosclerosis and stabilizes plaques in apolipoprotein E-deficient mice
Qin Hu et al.
HUMAN GENE THERAPY (2008)
An improved zinc-finger nuclease architecture for highly specific genome editing
Jeffrey C. Miller et al.
NATURE BIOTECHNOLOGY (2007)
Marfan syndrome: clinical diagnosis and management
John C. S. Dean
EUROPEAN JOURNAL OF HUMAN GENETICS (2007)
A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol
Tommaso Fasano et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Aneurysm syndromes caused by mutations in the TGF-β receptor
Bart L. Loeys et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
JC Cohen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Adeno-associated virus serotypes: Vector toolkit for human gene therapy
Zhijian Wu et al.
MOLECULAR THERAPY (2006)
Leukocyte engagement of platelet glycoprotein Ibα via the integrin Mac-1 is critical for the biological response to vascular injury
YM Wang et al.
CIRCULATION (2005)
Packaging capacity of adeno-associated virus serotypes: Impact of larger genomes on infectivity and postentry steps
JC Grieger et al.
JOURNAL OF VIROLOGY (2005)
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
BL Loeys et al.
NATURE GENETICS (2005)
Potent inhibition of arterial intimal hyperplasia by TIMP1 gene transfer using AAV vectors
GAR Correa et al.
MOLECULAR THERAPY (2004)
Monogenic hypercholesterolemia: new insights in pathogenesis and treatment
DJ Rader et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Latent transforming growth factor β-binding protein 1 interacts with fibrillin and is a microfibril-associated protein
Z Isogai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Morphological predictors of restenosis after coronary stenting in humans
A Farb et al.
CIRCULATION (2002)
Identification of genes that are associated with DNA repeats in prokaryotes
R Jansen et al.
MOLECULAR MICROBIOLOGY (2002)
Adenovirus-mediated gene transfer of a secreted transforming growth factor-β type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition
PA Kingston et al.
CIRCULATION (2001)
Optimization of nonviral gene transfer of vascular smooth muscle cells in vitro and in vivo
S Armeanu et al.
MOLECULAR THERAPY (2000)
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
KB Lane et al.
NATURE GENETICS (2000)