期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2021.798699
关键词
endocan; atherosclerosis; inflammation; endothelial dysfunction; CVD
资金
- Natural Science Foundation of China [82170485]
- Natural Science Foundation of Hunan Province, China [2019JJ40249]
- Key Project of Hunnan Provincial Department of Education [20A427]
- Ministry of Education Industry-University Cooperation Collaborative Education Project [202002138007]
- Hunan Provincial Innovation Foundation For Postgraduate [CX20200960]
Endocan, also known as endothelial cell specific molecule-1, is a soluble proteoglycan mainly secreted by endothelial cells. Increased plasma levels of endocan may reflect endothelial activation and dysfunction, and are considered a potential immuno-inflammatory marker related to cardiovascular disease. Endocan shows promise as a prognostic biomarker for cardiovascular disease, but further research into its mechanisms of action is needed.
Endothelial dysfunction is considered to be an early change in atherosclerosis. Endocan, also known as endothelial cell specific molecule-1, is a soluble proteoglycan mainly secreted by endothelial cells. Inflammatory factors such as IL-1 beta and TNF-alpha can up regulate the expression of endocan and then affect the expression of cell adhesion molecules, such as ICAM-1 and VCAM-1, which play an important role in promoting leukocyte migration and inflammatory response. Elevated plasma levels of endocan may reflect endothelial activation and dysfunction, and is considered to be a potential immuno-inflammatory marker that may be related to cardiovascular disease. In the case of hypertension, diabetes, angina pectoris and acute myocardial infarction, the increase or decrease of serum endocan levels is of great significance. Here, we reviewed the current research on endocan, and emphasis its possible clinical value as a prognostic marker of cardiovascular disease. Endocan may be a useful biomarker for the prognosis of cardiovascular disease, but more research is needed on its mechanism of action.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据