Data Assimilation by Stochastic Ensemble Kalman Filtering to Enhance Turbulent Cardiovascular Flow Data From Under-Resolved Observations

We propose a data assimilation methodology that can be used to enhance the spatial and temporal resolution of voxel-based data as it may be obtained from biomedical imaging modalities. It can be used to improve the assessment of turbulent blood flow in large vessels by combining observed data with a computational fluid dynamics solver. The methodology is based on a Stochastic Ensemble Kalman Filter (SEnKF) approach and geared toward pulsatile and turbulent flow configurations. We describe the observed flow fields by a mean value and its covariance. These flow fields are combined with forecasts obtained from a direct numerical simulation of the flow field. The method is validated against canonical pulsatile and turbulent flows. Finally, it is applied to a clinically relevant configuration, namely the flow downstream of a bioprosthetic valve in an aorta phantom. It is demonstrated how the 4D flow field obtained from experimental observations can be enhanced by the data assimilation algorithm. Results show that the presented method is promising for future use with in vivo data from 4D Flow Magnetic Resonance Imaging (4D Flow MRI). 4D Flow MRI returns spatially and temporally averaged flow fields that are limited by the spatial and the temporal resolution of the tool. These averaged flow fields and the associated uncertainty might be used as observation data in the context of the proposed methodology.

Automated summary

The proposed data assimilation methodology aims to enhance the spatial and temporal resolution of voxel-based data obtained from biomedical imaging modalities, specifically focusing on turbulent blood flow assessment in large vessels. The methodology, utilizing a Stochastic Ensemble Kalman Filter approach, combines observed flow fields with numerical simulations to improve the accuracy of flow field predictions. Validation against canonical flows and application to a clinically relevant scenario demonstrate the potential of the method to enhance 4D flow MRI data for future use.