期刊
PHARMACEUTICALS
卷 15, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ph15020130
关键词
aescin; glucocorticoid-like activity; benign prostatic hyperplasia; inflammation; IL-1 beta; TNF-alpha; COX-2; PCNA; TGF-beta; testosterone
资金
- Deanship of Scientific Research at Umm Al-Qura University [22UQU4290565DSR01]
The study demonstrates the protective effect of aescin against the development of BPH in rats by suppressing inflammation and proliferation. Further studies should focus on the clinical application of aescin in BPH management.
Background: Benign prostatic hyperplasia (BPH) is the most common urogenital condition in aging males, while inflammation and tissue proliferation constitute the main pathophysiological factors. The adverse effects of currently available BPH medications limit patient compliance. We tested the protective effect of aescin against the development of BPH in rats. Methods: A total of 18 male Wistar rats were divided into 3 groups: control (sesame oil 1 mL/kg, s.c.); BPH (testosterone oenanthate 3 mg/kg, s.c., in sesame oil), and BPH-aescin rats (testosterone oenanthate 3 mg/kg, s.c. + aescin 10 mg/kg/day, p.o.). All treatments continued for 4 weeks. Serum and prostatic samples were harvested for biochemical and histopathological examination. Results: Induction of BPH by testosterone increased the prostate weight and prostate weight index, serum testosterone, prostate expression of inflammatory (IL-1 beta, TNF-alpha, and COX-2), and proliferative markers (PCNA and TGF-beta 1). Concurrent treatment with aescin decreased the testosterone-induced increase in prostatic IL-1 beta, TNF-alpha, and COX-2 expression by 47.9%, 71.2%, and 64.4%, respectively. Moreover, aescin reduced the prostatic proliferation markers TGF-beta 1 and PCNA by 58.3% and 71.9%, respectively, and normalized the prostate weight. Conclusion: The results of this study showed, for the first time, that aescin protected against the development of experimental BPH in rats via its anti-inflammatory and antiproliferative effects. These findings warrant further studies to clinically repurpose aescin in the management of BPH.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据