4.6 Article

Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?

期刊

PHARMACEUTICALS
卷 15, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/ph15020231

关键词

late sodium current; cardiac sodium channel; arrhythmia

资金

  1. National Research Development and Innovation Office [NKFIH-K115397, NKFIH-K138090, NKFIH-FK128116]
  2. European Union [GINOP-2.3.2-15-2016-00040, EFOP-3.6.2-16-2017-00006]
  3. European Regional Development Fund [GINOP-2.3.2-15-2016-00040, EFOP-3.6.2-16-2017-00006]
  4. Thematic Excellence Program of the Ministry for Innovation and Technology in Hungary within University of Debrecen [TKP-2020-NKA-04]
  5. EU [EFOP-3.6.3-VEKOP16-2017-00009]
  6. European Social Fund [EFOP-3.6.3-VEKOP16-2017-00009]
  7. New National Excellence Program of the Ministry for Innovation and Technology from the National Research Development and Innovation Fund [UNKP-21-3]

向作者/读者索取更多资源

This article discusses the role of late sodium current in dysrhythmia and contractile malfunction in the heart, and highlights the recent advances in this field.
Late sodium current has long been linked to dysrhythmia and contractile malfunction in the heart. Despite the increasing body of accumulating information on the subject, our understanding of its role in normal or pathologic states is not complete. Even though the role of late sodium current in shaping action potential under physiologic circumstances is debated, it's unquestioned role in arrhythmogenesis keeps it in the focus of research. Transgenic mouse models and isoform-specific pharmacological tools have proved useful in understanding the mechanism of late sodium current in health and disease. This review will outline the mechanism and function of cardiac late sodium current with special focus on the recent advances of the area.

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