期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/jpm11100987
关键词
gut microbiota; schizophrenia; depression; anxiety; probiotics; functional genes
资金
- Morinaga Milk Industry Co., Ltd
- Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Young Scientists [19K20171]
- Daiichi Sankyo, Dainippon Sumitomo Pharma
- Grants-in-Aid for Scientific Research [19K20171] Funding Source: KAKEN
A recent study found that the predicted functional profile of the gut microbiota influences the effectiveness of probiotic treatment in patients with schizophrenia. Responders showed elevated lipid and energy metabolism at baseline compared to non-responders, highlighting the importance of assessing gut microbial functional genes before probiotic therapy initiation in patients with psychiatric disorders.
A recent meta-analysis found that probiotics have moderate-to-large beneficial effects on depressive symptoms in patients with psychiatric disorders. However, it remains unclear how the baseline gut microbiota before probiotic administration influences the host's response to probiotics. Therefore, we aimed to determine whether the predicted functional profile of the gut microbiota influences the effectiveness of probiotic treatment in patients with schizophrenia. A total of 29 patients with schizophrenia consumed Bifidobacterium breve A-1 (synonym B. breve MCC1274) for 4 weeks. We considered patients who showed a 25% or more reduction in the Hospital Anxiety and Depression Scale total score at 4 weeks from baseline to be responders and those who did not to be non-responders . We predicted the gut microbial functional genes based on 16S rRNA gene sequences and applied the linear discriminant analysis effect size method to determine the gut microbial functional genes most likely to explain the differences between responders and non-responders at baseline. The results showed that lipid and energy metabolism was elevated at baseline in responders (n = 12) compared to non-responders (n = 17). These findings highlight the importance of assessing the gut microbial functional genes at baseline before probiotic therapy initiation in patients with psychiatric disorders.
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