4.7 Article

Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy

期刊

JOURNAL OF PERSONALIZED MEDICINE
卷 11, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/jpm11111100

关键词

telomere; ECT; treatment-resistance; accelerated aging; psychiatric disorders; mental disorders; GWAS; bipolar disorder; major depressive disorder; senescence

资金

  1. Autonomous Region of Sardinia [RASSR57271, 7]
  2. Fondo integrativo per la ricerca (Fir)
  3. Sardinian Regional Government

向作者/读者索取更多资源

Psychiatric disorders may exhibit premature cell senescence, but the relationship between leukocyte telomere length (LTL) and response to electroconvulsive therapy (ECT) is inconclusive. LTL was found to be shorter in patients with treatment-resistant major depressive disorder (MDD) and bipolar disorder (BD) compared to controls, but baseline LTL was not predictive of ECT response. No significant overlap between genetic variants associated with LTL and ECT response was observed.
Psychiatric disorders seem to be characterized by premature cell senescence. However, controversial results have also been reported. In addition, the relationship between accelerated aging and treatment-resistance has scarcely been investigated. In the current study, we measured leukocyte telomere length (LTL) in 148 patients with treatment-resistant depression (TRD, 125 with major depressive disorder, MDD, and 23 with bipolar disorder, BD) treated with electroconvulsive therapy (ECT) and analyzed whether LTL was associated with different response profiles. We also compared LTL between patients with TRD and 335 non-psychiatric controls. For 107 patients for which genome-wide association data were available, we evaluated whether a significant overlap among genetic variants or genes associated with LTL and with response to ECT could be observed. LTL was negatively correlated with age (Spearman's correlation coefficient = -0.25, p < 0.0001) and significantly shorter in patients with treatment-resistant MDD (Quade's F = 35.18, p < 0.0001) or BD (Quade's F = 20.84, p < 0.0001) compared to controls. Conversely, baseline LTL was not associated with response to ECT or remission. We did not detect any significant overlap between genetic variants or genes associated with LTL and response to ECT. Our results support previous findings suggesting premature cell senescence in patients with severe psychiatric disorders and suggest that LTL could not be a predictive biomarker of response to ECT.

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