期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/jpm12010016
关键词
infarction; risk factors in epidemiology; outcome research; association rule mining; body mass index
资金
- National Research Fund of Korea [NRF-2019R1G1A1097707]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI)
- Ministry of Health & Welfare, Republic of Korea [HR21C0198]
- R&D Program for Forest Science Technology, Korea Forest Service (Korea Forestry Promotion Institute) [2021397C10-2123-0107, 2021397B10-2123-0107]
- Korea Forestry Promotion Institute (KOFPI) [2021397B10-2123-0107, 2021397C10-2123-0107] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study examined the obesity paradox in patients with acute ischemic stroke using binary logistic regression and association rule mining. The results showed that obesity had a beneficial effect on stroke outcome in the logistic regression analysis, and obese patients with good outcomes were also associated with younger age and mild stroke severity according to the association rule mining analysis.
Though obesity is generally associated with the development of cardiovascular disease (CVD) risk factors, previous reports have also reported that obesity has a beneficial effect on CVD outcomes. We aimed to verify the existing obesity paradox through binary logistic regression (BLR) and clarify the paradox via association rule mining (ARM). Patients with acute ischemic stroke (AIS) were assessed for their 3-month functional outcome using the modified Rankin Scale (mRS) score. Predictors for poor outcome (mRS 3-6) were analyzed through BLR, and ARM was performed to find out which combination of risk factors was concurrently associated with good outcomes using maximal support, confidence, and lift values. Among 2580 patients with AIS, being obese (OR [odds ratio], 0.78; 95% CI, 0.62-0.99) had beneficial effects on the outcome at 3 months in BLR analysis. In addition, the ARM algorithm showed obese patients with good outcomes were also associated with an age less than 55 years and mild stroke severity. While BLR analysis showed a beneficial effect of obesity on stroke outcome, in ARM analysis, obese patients had a relatively good combination of risk factor profiles compared to normal BMI patients. These results may partially explain the obesity paradox phenomenon in AIS patients.
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